|Other Names||Tapasin, TPN, TPSN, NGS-17, TAP-associated protein, TAP-binding protein, TAPBP, NGS17, TAPA|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading).|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type I membrane protein|
|Tissue Location||Neutrophils, mostly in fully differentiated cells|
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This gene encodes a transmembrane glycoprotein whichmediates interaction between newly assembled majorhistocompatibility complex (MHC) class I molecules and thetransporter associated with antigen processing (TAP), which isrequired for the transport of antigenic peptides across theendoplasmic reticulum membrane. This interaction is essential foroptimal peptide loading on the MHC class I molecule. Up to fourcomplexes of MHC class I and this protein may be bound to a singleTAP molecule. This protein contains a C-terminal double-lysinemotif (KKKAE) known to maintain membrane proteins in theendoplasmic reticulum. This gene lies within the majorhistocompatibility complex on chromosome 6. Alternative splicingresults in three transcript variants encoding different isoforms.
Jiang, Q., et al. Tumour Biol. 31(5):451-459(2010)Rizvi, S.M., et al. Traffic 11(3):332-347(2010)Praveen, P.V., et al. Eur. J. Immunol. 40(1):214-224(2010)Barcellos, L.F., et al. PLoS Genet. 5 (10), E1000696 (2009) :Lindquist, J.A., et al. EMBO J. 17(8):2186-2195(1998)
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