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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   mouse CASP3 Antibody (N-term S12) Blocking Peptide   

mouse CASP3 Antibody (N-term S12) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P70677
Clone Names 111026064
Peptide ID 111026064
Additional Information
Gene ID 12367
Other Names Caspase-3, CASP-3, Apopain, Cysteine protease CPP32, CPP-32, LICE, Protein Yama, SREBP cleavage activity 1, SCA-1, Caspase-3 subunit p17, Caspase-3 subunit p12, Casp3, Cpp32
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Casp3
Synonyms Cpp32
Function Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes.
Cellular Location Cytoplasm.
Tissue Location Highest expression in spleen, lung, liver, kidney and heart. Lower expression in brain, skeletal muscle and testis
Research Areas
Citations (0)

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Background

CASP3 is involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9 (By similarity). Cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes.

References

Srikanth, C.V., et al. Science 330(6002):390-393(2010)Li, F., et al. Cell Stem Cell 7(4):508-520(2010)Wang, L., et al. J. Neurosci. 30(39):13201-13210(2010)Gascon, E., et al. J. Neurosci. 30(37):12414-12423(2010)Bohsali, A., et al. BMC Microbiol. 10, 237 (2010) :

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$ 80.00
Cat# BP18708a
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