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FOXP3 Antibody (C-term S418) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9BZS1
Clone Names 80522022
Peptide ID 80522022
Additional Information
Gene ID 50943
Other Names Forkhead box protein P3, Scurfin, FOXP3, IPEX
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name FOXP3
Synonyms IPEX
Function Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon- gamma (IFNG). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2 (PubMed:15790681). Mediates transcriptional repression of IL2 via its association with histone acetylase KAT5 and histone deacetylase HDAC7 (PubMed:17360565). Can activate the expression of TNFRSF18, IL2RA and CTLA4 and repress the expression of IL2 and IFNG via its association with transcription factor RUNX1 (PubMed:17377532). Inhibits the differentiation of IL17 producing helper T-cells (Th17) by antagonizing RORC function, leading to down-regulation of IL17 expression, favoring Treg development (PubMed:18368049). Inhibits the transcriptional activator activity of RORA (PubMed:18354202). Can repress the expression of IL2 and IFNG via its association with transcription factor IKZF4 (By similarity).
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00089, ECO:0000269|PubMed:17360565, ECO:0000269|PubMed:18354202, ECO:0000269|PubMed:22678915, ECO:0000269|PubMed:23396208, ECO:0000269|PubMed:23973222, ECO:0000269|PubMed:23973223}. Cytoplasm. Note=Predominantly expressed in the cytoplasm in activated conventional T-cells whereas predominantly expressed in the nucleus in regulatory T-cells (Treg). The 41 kDa form derived by proteolytic processing is found exclusively in the chromatin fraction of activated Treg cells (By similarity) {ECO:0000250|UniProtKB:Q99JB6, ECO:0000269|PubMed:22678915}
Research Areas
Citations (0)

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The protein encoded by this gene is a member of theforkhead/winged-helix family of transcriptional regulators. Defectsin this gene are the cause of immunodeficiency polyendocrinopathy,enteropathy, X-linked syndrome (IPEX), also known as X-linkedautoimmunity-immunodeficiency syndrome. Alternatively splicedtranscript variants encoding different isoforms have beenidentified.


Nadeau, K., et al. J. Allergy Clin. Immunol. 126(4):845-852(2010)Gandhi, R., et al. Nat. Immunol. 11(9):846-853(2010)Lan, Y., et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 27(4):433-436(2010)Comperat, E., et al. Anal. Quant. Cytol. Histol. 32(1):39-44(2010)Atfy, M., et al. Egypt J Immunol 16(1):117-126(2009)

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$ 80.00
Cat# BP18718b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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