|Other Names||Protein phosphatase 1 regulatory subunit 1C, Inhibitor-5 of protein phosphatase 1, IPP5, PPP1R1C|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Inhibitor of protein-phosphatase 1. Promotes cell growth and cell cycle progress at the G1/S transition. May increase cell susceptibility to TNF-induced apoptosis.|
|Tissue Location||Expressed in heart, skeletal muscle, liver and testis (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
Protein phosphatase-1 (PP1) is a major serine/threoninephosphatase that regulates a variety of cellular functions. PP1consists of a catalytic subunit (see PPP1CA; MIM 176875) andregulatory subunits that determine the subcellular localization ofPP1 or regulate its function. PPP1R1C belongs to a group of PP1inhibitory subunits that are themselves regulated byphosphorylation (Wang et al., 2008 [PubMed 18310074]).[supplied byOMIM].
Dick, D.M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2010) In press :Rose, J. Phd, et al. Mol. Med. (2010) In press :Zeng, Q., et al. Biotechnol. Appl. Biochem. 54(4):231-238(2009)Wang, X., et al. J. Biol. Chem. 283(18):12076-12084(2008)Ceulemans, H., et al. Bioessays 24(4):371-381(2002)
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