|Other Names||Transcription factor Dp family member 3, Cancer/testis antigen 30, CT30, Hepatocellular carcinoma-associated antigen 661, TFDP3, DP4, HCA661|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Competitive inhibitor of E2F-mediated transactivation activity. Impairs E2F-mediated cell-cycle progression from G(1) to S phase.|
|Cellular Location||Nucleus. Cytoplasm. Note=Translocates to the nucleus on heterodimerization with E2F family members|
|Tissue Location||Predominantly expressed in testis. Low level of expression in pancreas. Highly expressed in ovarian and colon cancer cell lines.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the DP family oftranscription factors. These factors heterodimerize with E2Fproteins to enhance their DNA-binding activity and promotetranscription from E2F target genes. This protein functions as anegative regulator and inhibits the DNA binding and transcriptionalactivities of E2F factors.
Tian, C., et al. Biochem. Biophys. Res. Commun. 361(1):20-25(2007)Qiao, H., et al. J. Biol. Chem. 282(1):454-466(2007)Milton, A., et al. Oncogene 25(22):3212-3218(2006)
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