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CLN8 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9UBY8 |
|---|---|
| Clone Names | 100324092 |
| Gene ID | 2055 |
|---|---|
| Other Names | Protein CLN8, CLN8, C8orf61 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CLN8 |
|---|---|
| Synonyms | C8orf61 |
| Function | Could play a role in cell proliferation during neuronal differentiation and in protection against cell death. |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Endoplasmic reticulum |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a transmembrane protein belonging to afamily of proteins containing TLC domains, which are postulated tofunction in lipid synthesis, transport, or sensing. The proteinlocalizes to the endoplasmic reticulum (ER), and may recyclebetween the ER and ER-Golgi intermediate compartment. Mutations inthis gene are associated with progressive epilepsy with mentalretardation (EMPR), which is a subtype of neuronal ceroidlipofuscinoses (NCL). Patients with mutations in this gene havealtered levels of sphingolipid and phospholipids in the brain.
References
Reinhardt, K., et al. Clin. Genet. 77(1):79-85(2010)Vantaggiato, C., et al. Hum. Mutat. 30(7):1104-1116(2009)Kousi, M., et al. Brain 132 (PT 3), 810-819 (2009) :Striano, P., et al. Epilepsy Behav 10(1):187-191(2007)Hermansson, M., et al. J. Neurochem. 95(3):609-617(2005)
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