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Mlf1 Antibody (N-term S34) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P58340
Clone Names 3011007
Peptide ID 3011007
Additional Information
Gene ID 4291
Other Names Myeloid leukemia factor 1, Myelodysplasia-myeloid leukemia factor 1, MLF1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MLF1
Function Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.
Cellular Location Cytoplasm. Nucleus. Note=In non- hematopoietic cells, resides primarily in the cytoplasm with some punctate nuclear localization. Shuttles between the cytoplasm and nucleus. In hematopoietic cells, located preferentially in the nucleus. Found in the nucleolus when fused to NPM
Tissue Location Most abundant in testis, ovary, skeletal muscle, heart, kidney and colon. Low expression in spleen, thymus and peripheral blood leukocytes
Research Areas
Citations (0)

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This gene encodes an oncoprotein which is thought to playa role in the phenotypic determination of hemopoetic cells.Translocations between this gene and nucleophosmin have beenassociated with myelodysplastic syndrome and acute myeloidleukemia. Multiple transcript variants encoding different isoformshave been found for this gene.


Lim, G., et al. Cancer Genet. Cytogenet. 199(2):101-109(2010)Luke, M.M., et al. Stroke 40(2):363-368(2009)Li, Z.F., et al. J. Neurol. Sci. 264 (1-2), 77-86 (2008) :Shiffman, D., et al. Arterioscler. Thromb. Vasc. Biol. 28(1):173-179(2008)Yoneda-Kato, N., et al. Mol. Cell. Biol. 28(1):422-434(2008)

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$ 80.00
Cat# BP18730a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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