Mlf1 Antibody (N-term S34) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P58340 |
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Clone Names | 3011007 |
Gene ID | 4291 |
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Other Names | Myeloid leukemia factor 1, Myelodysplasia-myeloid leukemia factor 1, MLF1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | MLF1 |
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Function | Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus. |
Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q9QWV4}. Nucleus {ECO:0000250|UniProtKB:Q9QWV4}. Cell projection, cilium {ECO:0000250|UniProtKB:Q9QWV4}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q9QWV4}. Note=Shuttles between the cytoplasm and nucleus. {ECO:0000250|UniProtKB:Q9QWV4} |
Tissue Location | Most abundant in testis, ovary, skeletal muscle, heart, kidney and colon. Low expression in spleen, thymus and peripheral blood leukocytes |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes an oncoprotein which is thought to playa role in the phenotypic determination of hemopoetic cells.Translocations between this gene and nucleophosmin have beenassociated with myelodysplastic syndrome and acute myeloidleukemia. Multiple transcript variants encoding different isoformshave been found for this gene.
References
Lim, G., et al. Cancer Genet. Cytogenet. 199(2):101-109(2010)Luke, M.M., et al. Stroke 40(2):363-368(2009)Li, Z.F., et al. J. Neurol. Sci. 264 (1-2), 77-86 (2008) :Shiffman, D., et al. Arterioscler. Thromb. Vasc. Biol. 28(1):173-179(2008)Yoneda-Kato, N., et al. Mol. Cell. Biol. 28(1):422-434(2008)
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