|Other Names||F-box only protein 8, F-box/SEC7 protein FBS, FBXO8, FBS, FBX8|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of GDP with GTP (Potential).|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the F-box protein familywhich is characterized by an approximately 40 amino acid motif, theF-box. The F-box proteins constitute one of the four subunits ofthe ubiquitin protein ligase complex called SCFs(SKP1-cullin-F-box), which function in phosphorylation-dependentubiquitination. The F-box proteins are divided into 3 classes: Fbwscontaining WD-40 domains, Fbls containing leucine-rich repeats, andFbxs containing either different protein-protein interactionmodules or no recognizable motifs. The protein encoded by this genebelongs to the Fbxs class. It contains a C-terminal amino acidsequence that bears a significant similarity with a portion ofyeast Sec7p, a critical regulator of vesicular protein transport.This human protein may interact with ADP-ribosylationfactor(s)(ARFs) and exhibit ARF-GEF (guanine nucleotide exchangefactor) activity.
Cronin, S., et al. Eur. J. Hum. Genet. 17(2):213-218(2009)Lamesch, P., et al. Genomics 89(3):307-315(2007)Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)Ilyin, G.P., et al. Genomics 67(1):40-47(2000)Winston, J.T., et al. Curr. Biol. 9(20):1180-1182(1999)
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