|Other Names||28S ribosomal protein S31, mitochondrial, MRP-S31, S31mt, Imogen 38, MRPS31, IMOGN38|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Mitochondrion. EMBL; Z68747; CAA92951.1; -; mRNA EMBL; AK315248; BAG37670.1; -; mRNA EMBL; AL355132; CAH70977.1; -; Genomic_DNA EMBL; AL161614; CAH70977.1; JOINED; Genomic_DNA EMBL; AL161614; CAH72771.1; -; Genomic_DNA EMBL; AL355132; CAH72771.1; JOINED; Genomic_DNA EMBL; CH471075; EAX08629.1; -; Genomic_DNA EMBL; BC022045; AAH22045.1; -; mRNA CCDS; CCDS9372.1; - RefSeq; NP_005821.2; NM_005830.3 UniGene; Hs.596607; - PDB; 3J9M; EM; 3.50 A; AY=1-395 PDBsum; 3J9M; - ProteinModelPortal; Q92665; - SMR; Q92665; - BioGrid; 115534; 71 IntAct; Q92665; 16 MINT; MINT-1420773; - STRING; 9606.ENSP00000315397; - iPTMnet; Q92665; - PhosphoSitePlus; Q92665; - BioMuta; MRPS31; - DMDM; 93186129; - EPD; Q92665; - MaxQB; Q92665; - PaxDb; Q92665; - PeptideAtlas; Q92665; - PRIDE; Q92665; - DNASU; 10240; - Ensembl; ENST00000323563; ENSP00000315397; ENSG00000102738 GeneID; 10240; - KEGG; hsa:10240; - UCSC; uc001uxm.5; human CTD; 10240; - DisGeNET; 10240; - GeneCards; MRPS31; - HGNC; HGNC:16632; MRPS31 HPA; HPA039083; - HPA; HPA046344; - MIM; 611992; gene neXtProt; NX_Q92665; - OpenTargets; ENSG00000102738; - PharmGKB; PA31019; - eggNOG; ENOG410IHXJ; Eukaryota eggNOG; ENOG4111GGB; LUCA GeneTree; ENSGT00390000010017; - HOGENOM; HOG000232111; - HOVERGEN; HBG036128; - InParanoid; Q92665; - KO; K17410; - OMA; KESNIQF; - OrthoDB; EOG091G0LP5; - PhylomeDB; Q92665; - TreeFam; TF324305; - BioCyc; ZFISH:ENSG00000102738-MONOMER; - Reactome; R-HSA-5368286; Mitochondrial translation initiation Reactome; R-HSA-5389840; Mitochondrial translation elongation Reactome; R-HSA-5419276; Mitochondrial translation termination GenomeRNAi; 10240; - PRO; PR:Q92665; - Proteomes; UP000005640; Chromosome 13 Bgee; ENSG00000102738; - CleanEx; HS_MRPS31; - Genevisible; Q92665; HS GO; GO:0005743; C:mitochondrial inner membrane; TAS:Reactome GO; GO:0005763; C:mitochondrial small ribosomal subunit; IEA:InterPro GO; GO:0005739; C:mitochondrion; IDA:HPA GO; GO:0005730; C:nucleolus; IDA:HPA GO; GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB GO; GO:0019904; F:protein domain specific binding; IPI:UniProtKB GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro GO; GO:0070125; P:mitochondrial translational elongation; TAS:Reactome GO; GO:0070126; P:mitochondrial translational termination; TAS:Reactome InterPro; IPR026299; MRP-S31 PANTHER; PTHR13231; PTHR13231; 1 Pfam; PF15433; MRP-S31; 1 1: Evidence at protein level; 3D-structure; Complete proteome; Mitochondrion; Polymorphism; Reference proteome; Ribonucleoprotein; Ribosomal protein; Transit peptide TRANSIT 1 65 Mitochondrion. CHAIN 66 395 28S ribosomal protein S31, mitochondrial /FTId=PRO_0000030594 VARIANT 241 241 T -> M (in dbSNP:rs1854421) /FTId=VAR_052049 VARIANT 279 279 D -> N (in dbSNP:rs13508) /FTId=VAR_061812 CONFLICT 80 80 T -> I (in Ref. 5; AAH22045) CONFLICT 132 132 T -> A (in Ref. 5; AAH22045) SEQUENCE 395 AA; 45318 MW; 01ED04983ED56818 CRC64; MFPRVSTFLP LRPLSRHPLS SGSPETSAAA IMLLTVRHGT VRYRSSALLA RTKNNIQRYF GTNSVICSKK DKQSVRTEET SKETSESQDS EKENTKKDLL GIIKGMKVEL STVNVRTTKP PKRRPLKSLE ATLGRLRRAT EYAPKKRIEP LSPELVAAAS AVADSLPFDK QTTKSELLSQ LQQHEEESRA QRDAKRPKIS FSNIISDMKV ARSATARVRS RPELRIQFDE GYDNYPGQEK TDDLKKRKNI FTGKRLNIFD MMAVTKEAPE TDTSPSLWDV EFAKQLATVN EQPLQNGFEE LIQWTKEGKL WEFPINNEAG FDDDGSEFHE HIFLEKHLES FPKQGPIRHF MELVTCGLSK NPYLSVKQKV EHIEWFRNYF NEKKDILKES NIQFN|
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Provided below are standard protocols that you may find useful for product applications.
Mammalian mitochondrial ribosomal proteins are encoded bynuclear genes and help in protein synthesis within themitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of asmall 28S subunit and a large 39S subunit. They have an estimated75% protein to rRNA composition compared to prokaryotic ribosomes,where this ratio is reversed. Another difference between mammalianmitoribosomes and prokaryotic ribosomes is that the latter containa 5S rRNA. Among different species, the proteins comprising themitoribosome differ greatly in sequence, and sometimes inbiochemical properties, which prevents easy recognition by sequencehomology. The 28S subunit of the mammalian mitoribosome may play acrucial and characteristic role in translation initiation. Thisgene encodes a 28S subunit protein that has also been associatedwith type 1 diabetes; however, its relationship to the etiology ofthis disease remains to be clarified. Pseudogenes corresponding tothis gene have been found on chromosomes 3 and 13. [provided byRefSeq].
Dunham, A., et al. Nature 428(6982):522-528(2004)Zhang, Z., et al. Genomics 81(5):468-480(2003)Tchernev, V.T., et al. Mol. Med. 8(1):56-64(2002)Cavdar Koc, E., et al. J. Biol. Chem. 276(22):19363-19374(2001)
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