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NLRP4 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q96MN2
Clone Names 110717125
Peptide ID 110717125
Additional Information
Gene ID 147945
Other Names NACHT, LRR and PYD domains-containing protein 4, Cancer/testis antigen 58, CT58, PAAD and NACHT-containing protein 2, PAN2, PYRIN and NACHT-containing protein 2, PYRIN-containing APAF1-like protein 4, PYPAF4, Ribonuclease inhibitor 2, NLRP4, NALP4, PAN2, PYPAF4, RNH2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NLRP4
Synonyms NALP4, PAN2, PYPAF4, RNH2
Function May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors. Acts as a negative regulator of the type I interferon signaling pathway by serving as an adapter to promote DTX4-mediated ubiquitination of activated TBK1, and its subsequent degradation. Suppresses NF-kappaB induction by the cytokines TNFA and IL1B, suggesting that it operates at a point of convergence in these two cytokine signaling pathways.
Research Areas
Citations (0)

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NALPs are cytoplasmic proteins that form a subfamilywithin the larger CATERPILLER protein family. Most short NALPs,such as NALP4, have an N-terminal pyrin (MEFV; MIM 608107) domain(PYD), followed by a NACHT domain, a NACHT-associated domain (NAD),and a C-terminal leucine-rich repeat (LRR) region. The long NALP,NALP1 (MIM 606636), also has a C-terminal extension containing afunction to find domain (FIIND) and a caspase recruitment domain(CARD). NALPs are implicated in the activation of proinflammatorycaspases (e.g., CASP1; MIM 147678) via their involvement inmultiprotein complexes called inflammasomes (Tschopp et al., 2003[PubMed 12563287]).


Cummings, J.R., et al. Tissue Antigens 76(1):48-56(2010)Enjuanes, A., et al. Cancer Res. 68(24):10178-10186(2008)Damiano, J.S., et al. Biochem. J. 381 (PT 1), 213-219 (2004) :Tschopp, J., et al. Nat. Rev. Mol. Cell Biol. 4(2):95-104(2003)Grenier, J.M., et al. FEBS Lett. 530 (1-3), 73-78 (2002) :

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$ 80.00
Cat# BP18739a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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