|Other Names||C-type lectin domain family 6 member A, C-type lectin superfamily member 10, Dendritic cell-associated C-type lectin 2, DC-associated C-type lectin 2, Dectin-2, CLEC6A, CLECSF10, DECTIN2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds high-mannose carbohydrates in a Ca(2+)-dependent manner (PubMed:28652405). Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the host defense against C.albicans infection by inducing TH17 cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9-NF-kappa-B-dependent pathway (By similarity).|
|Cellular Location||Membrane; Single-pass type II membrane protein|
|Tissue Location||Expressed in lung, spleen, lymph node, leukocytes, bone marrow, tonsils and dendritic cells. Strongly expressed in purified monocytes and weakly in B-cells. In peripheral blood cells, preferentially expressed in plasmacytoids rather than myeloids.|
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Provided below are standard protocols that you may find useful for product applications.
Like dectin-1 (CLEC7A; MIM 606264), CLEC6A, or dectin-2,is a type II membrane receptor with an extracellular C-typelectin-like domain fold. However, unlike dectin-1, dectin-2 lacksan immunoreceptor tyrosine-based activation motif (ITAM) in itscytoplasmic domain (Kanazawa et al., 2004 [PubMed15175046]).
Gavino, A.C., et al. Exp. Dermatol. 14(4):281-288(2005)Flornes, L.M., et al. Immunogenetics 56(7):506-517(2004)Kanazawa, N., et al. J. Invest. Dermatol. 122(6):1522-1524(2004)
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