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CLEC6A Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q6EIG7 |
|---|---|
| Clone Names | 110729061 |
| Gene ID | 93978 |
|---|---|
| Other Names | C-type lectin domain family 6 member A, C-type lectin superfamily member 10, Dendritic cell-associated C-type lectin 2, DC-associated C-type lectin 2, Dectin-2, CLEC6A, CLECSF10, DECTIN2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CLEC6A (HGNC:14556) |
|---|---|
| Function | Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: specifically recognizes and binds alpha-mannans on C.albicans hypheas (PubMed:23911656, PubMed:28652405). Binding of C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes (By similarity). Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production (By similarity). Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses (By similarity). |
| Cellular Location | Cell membrane; Single-pass type II membrane protein |
| Tissue Location | Expressed in lung, spleen, lymph node, leukocytes, bone marrow, tonsils and dendritic cells. Strongly expressed in purified monocytes and weakly in B-cells. In peripheral blood cells, preferentially expressed in plasmacytoids rather than myeloids |
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Provided below are standard protocols that you may find useful for product applications.
Background
Like dectin-1 (CLEC7A; MIM 606264), CLEC6A, or dectin-2,is a type II membrane receptor with an extracellular C-typelectin-like domain fold. However, unlike dectin-1, dectin-2 lacksan immunoreceptor tyrosine-based activation motif (ITAM) in itscytoplasmic domain (Kanazawa et al., 2004 [PubMed15175046]).
References
Gavino, A.C., et al. Exp. Dermatol. 14(4):281-288(2005)Flornes, L.M., et al. Immunogenetics 56(7):506-517(2004)Kanazawa, N., et al. J. Invest. Dermatol. 122(6):1522-1524(2004)
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