|Other Names||Replication protein A 30 kDa subunit, RP-A p30, Replication factor A protein 4, RF-A protein 4, RPA4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.|
|Cellular Location||Nucleus. Note=Localizes to DNA repair foci after DNA damage|
|Tissue Location||Preferentially expressed in placental and colon mucosa. Widely expressed at intermediate or lower levels|
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This gene encodes a single-stranded DNA-binding proteinthat is the 30-kDa subunit of the replication protein A complex.Replication protein A is an essential factor for DNA double-strandbreak repair and cell cycle checkpoint activation. The encodedprotein localizes to DNA repair foci and may be involved in thecellular DNA damage response. This protein may also play a role ininhibiting viral replication.
Kemp, M.G., et al. J. Biol. Chem. 285(7):4788-4797(2010)Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010)Haring, S.J., et al. Nucleic Acids Res. 38(3):846-858(2010)Shen, M., et al. Environ. Mol. Mutagen. 50(4):285-290(2009)Mason, A.C., et al. J. Biol. Chem. 284(8):5324-5331(2009)
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