|Other Names||Replication protein A 30 kDa subunit, RP-A p30, Replication factor A protein 4, RF-A protein 4, RPA4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.|
|Cellular Location||Nucleus. Note=Localizes to DNA repair foci after DNA damage|
|Tissue Location||Preferentially expressed in placental and colon mucosa. Widely expressed at intermediate or lower levels|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This gene encodes a single-stranded DNA-binding proteinthat is the 30-kDa subunit of the replication protein A complex.Replication protein A is an essential factor for DNA double-strandbreak repair and cell cycle checkpoint activation. The encodedprotein localizes to DNA repair foci and may be involved in thecellular DNA damage response. This protein may also play a role ininhibiting viral replication.
Kemp, M.G., et al. J. Biol. Chem. 285(7):4788-4797(2010)Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010)Haring, S.J., et al. Nucleic Acids Res. 38(3):846-858(2010)Shen, M., et al. Environ. Mol. Mutagen. 50(4):285-290(2009)Mason, A.C., et al. J. Biol. Chem. 284(8):5324-5331(2009)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.