|Other Names||Suppressor of G2 allele of SKP1 homolog, Protein 40-6-3, Sgt1, SUGT1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in ubiquitination and subsequent proteasomal degradation of target proteins.|
|Cellular Location||Cytoplasm. Nucleus. Note=Translocates to the nucleus upon heat shock, requiring S100A6|
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Provided below are standard protocols that you may find useful for product applications.
This gene is homologous to the yeast gene SGT1, whichencodes a protein involved in kinetochore function and required forthe G1/S and G2/M transitions. Complementation studies suggest thatthe human protein has similar functions. Two transcript variantsencoding different isoforms have been found for this gene.
Davies, A.E., et al. J. Cell Biol. 189(2):261-274(2010)Iwatsuki, M., et al. Int. J. Oncol. 36(3):569-575(2010)Bansal, P.K., et al. J. Biol. Chem. 284(28):18692-18698(2009)Zabka, M., et al. Biochem. Biophys. Res. Commun. 370(1):179-183(2008)Spiechowicz, M., et al. Biochem. Biophys. Res. Commun. 357(4):1148-1153(2007)
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