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ZHX2 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9Y6X8 |
|---|---|
| Clone Names | 110819115 |
| Gene ID | 22882 |
|---|---|
| Other Names | Zinc fingers and homeoboxes protein 2, Alpha-fetoprotein regulator 1, AFP regulator 1, Regulator of AFP, Zinc finger and homeodomain protein 2, ZHX2, AFR1, KIAA0854, RAF |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ZHX2 |
|---|---|
| Synonyms | AFR1, KIAA0854, RAF |
| Function | Acts as a transcriptional repressor (PubMed:12741956). Represses the promoter activity of the CDC25C gene stimulated by NFYA (PubMed:12741956). May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells (By similarity). In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex (By similarity). |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:12741956, ECO:0000269|PubMed:17056598} Note=Colocalizes with EFNB1 intracellular domain in the nucleus {ECO:0000250|UniProtKB:Q8C0C0} |
| Tissue Location | Ubiquitously expressed. Expressed in podocytes. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The members of the zinc fingers and homeoboxes gene familyare nuclear homodimeric transcriptional repressors that interactwith the A subunit of nuclear factor-Y (NF-YA) and contain twoC2H2-type zinc fingers and five homeobox DNA-binding domains. Thisgene encodes member 2 of this gene family. In addition to forminghomodimers, this protein heterodimerizes with member 1 of the zincfingers and homeoboxes family.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Xu, J., et al. Proc. Natl. Acad. Sci. U.S.A. 107(5):2136-2140(2010)Trynka, G., et al. Gut 58(8):1078-1083(2009)Shen, H., et al. J. Cell. Mol. Med. 12 (6B), 2772-2780 (2008) :Hu, S., et al. Neoplasma 54(3):207-211(2007)
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