|Other Names||Stimulated by retinoic acid gene 6 protein homolog, Stra6|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May act as a high-affinity cell-surface receptor for the complex retinol-retinol binding protein (RBP/RBP4). Acts by removing retinol from RBP/RBP4 and transports it across the plasma membrane, where it can be metabolized. This mechanism does not depend on endocytosis. Binds to RBP/RBP4 with high affinity. Increases cellular retinol uptake from the retinol-RBP complex (By similarity).|
|Cellular Location||Cell membrane; Multi-pass membrane protein EMBL; BC097373; AAH97373.1; -; mRNA RefSeq; NP_001025095.1; NM_001029924.1 UniGene; Rn.12735; - ProteinModelPortal; Q4QR83; - STRING; 10116.ENSRNOP00000011074; - PhosphoSitePlus; Q4QR83; - PaxDb; Q4QR83; - PRIDE; Q4QR83; - Ensembl; ENSRNOT00000090588; ENSRNOP00000070968; ENSRNOG00000008312 GeneID; 363071; - KEGG; rno:363071; - UCSC; RGD:1307551; rat CTD; 64220; - RGD; 1307551; Stra6 eggNOG; ENOG410IDYH; Eukaryota eggNOG; ENOG410YGRH; LUCA GeneTree; ENSGT00390000015272; - HOGENOM; HOG000154441; - HOVERGEN; HBG106311; - InParanoid; Q4QR83; - OrthoDB; EOG091G05AQ; - PhylomeDB; Q4QR83; - TreeFam; TF331851; - Reactome; R-RNO-2453902; The canonical retinoid cycle in rods (twilight vision) PRO; PR:Q4QR83; - Proteomes; UP000002494; Chromosome 8 Bgee; ENSRNOG00000008312; - ExpressionAtlas; Q4QR83; baseline and differential Genevisible; Q4QR83; RN GO; GO:0016021; C:integral component of membrane; IC:RGD GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell GO; GO:0004872; F:receptor activity; IC:RGD GO; GO:0051183; F:vitamin transporter activity; IC:RGD GO; GO:0042573; P:retinoic acid metabolic process; IEP:RGD GO; GO:0071939; P:vitamin A import; IEP:RGD InterPro; IPR026612; STRA6 PANTHER; PTHR21444:SF16; PTHR21444:SF16; 1 2: Evidence at transcript level; Cell membrane; Complete proteome; Glycoprotein; Membrane; Receptor; Reference proteome; Transmembrane; Transmembrane helix; Transport CHAIN 1 670 Stimulated by retinoic acid gene 6 protein homolog /FTId=PRO_0000311231 TOPO_DOM 1 50 Extracellular. TRANSMEM 51 71 Helical. TOPO_DOM 72 98 Cytoplasmic. TRANSMEM 99 119 Helical. TOPO_DOM 120 204 Extracellular. TRANSMEM 205 225 Helical. TOPO_DOM 226 296 Cytoplasmic. TRANSMEM 297 317 Helical. TOPO_DOM 318 325 Extracellular. TRANSMEM 326 346 Helical. TOPO_DOM 347 362 Cytoplasmic. TRANSMEM 363 383 Helical. TOPO_DOM 384 440 Extracellular. TRANSMEM 441 461 Helical. TOPO_DOM 462 475 Cytoplasmic. TRANSMEM 476 496 Helical. TOPO_DOM 497 510 Extracellular. TRANSMEM 511 531 Helical. TOPO_DOM 532 670 Cytoplasmic. CARBOHYD 8 8 N-linked (GlcNAc...). SEQUENCE 670 AA; 73763 MW; 4762A19CA3E816A6 CRC64; MESQASENGS QTSSGVTDDY SSWYIEEPLG AEEVQPEGVN PLCQPTVPPA LHHACLASLS LLALLLLALL VRRRRLWPHC AHCRPGLPSP VDFLAGNRSW TVPTAVFVAL FSNLCLLLPD ENPLPFLNRT AASSPDGEPE TSRGPWKLLA LLYYPALYYP LAACATAGHR AAYLLGTVLS WVHVSVQVWQ RAECPQDPKI YKHYSLLASL PLLLSLGFLS LWYPVQVVQS IRHRTGAGSQ GLQTSYSEKY LRALLCPKKL DSCSHPASKR SLLSRAWAFS QHSIYTPEPG FCLPLKLVIS ATLTGTATYQ VALLLLVSVV PTVQKVRAGI TTDVSYLLAG FGIVLSEDRQ EVVELVKHHL WAVEACYISA LVLSCSLTFL LLIRSLRTHR ANLKALHRGA ALDLGPPLQS THPSRQAIVC WMSFSAYQTA FSCLGLLVQQ VIFFLGTTIL AFLVFVPLLH GRNLLLLRSL ESTWPFWLTL VLAVILQNIA ANWVFLESHH GYPELTNRRM LCVATFLLFP INMLVGAIMA IWRVLLSSLY NTVHLGQMDL SLLPQRAASL DPGYHTYRNF LRIEASQSHP GVIAFCALLL HVPSPQPQPP LAPQDSLRPA AEEEGMQLLQ TKDLMAKGAG PKGSRSRARW GLAYTLLHNP SLQAFRKAAL TSAKANGTQP|
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Stra6 may act as a high-affinity cell-surface receptor for the complex retinol-retinol binding protein (RBP/RBP4). Acts by removing retinol from RBP/RBP4 and transports it across the plasma membrane, where it can be metabolized. This mechanism does not depend on endocytosis. Binds to RBP/RBP4 with high affinity. Increases cellular retinol uptake from the retinol-RBP complex (By similarity).
Strausberg, R.L., et al. Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903(2002)
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