|Other Names||1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon, 1-acylglycerol-3-phosphate O-acyltransferase 5, 1-AGP acyltransferase 5, 1-AGPAT 5, Lysophosphatidic acid acyltransferase epsilon, LPAAT-epsilon, AGPAT5|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C15:0-C20:4 at the sn-1 position using C18:1-CoA as the acyl donor. Also acts on lysophosphatidylethanolamine using oleoyl-CoA, but not arachidonoyl-CoA, and lysophosphatidylinositol using arachidonoyl-CoA, but not oleoyl-CoA. Activity toward lysophosphatidylglycerol not detectable.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus envelope. Mitochondrion|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the1-acylglycerol-3-phosphate O-acyltransferase family. This integralmembrane protein converts lysophosphatidic acid to phosphatidicacid, the second step in de novo phospholipid biosynthesis.
Rose, J. Phd, et al. Mol. Med. (2010) In press :Agarwal, A.K., et al. Arch. Biochem. Biophys. 449 (1-2), 64-76 (2006) :Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)Lu, B., et al. Biochem. J. 385 (PT 2), 469-477 (2005) :Leung, D.W. Front. Biosci. 6, D944-D953 (2001) :
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