|Other Names||DNA dC->dU-editing enzyme APOBEC-3D, A3D, 354-, APOBEC3D|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination- independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double- stranded RNA. May inhibit the mobility of LTR and non-LTR retrotransposons.|
|Cellular Location||Cytoplasm. Cytoplasm, P-body.|
|Tissue Location||Expressed in lymphoid organs. Also detected in non-lymphoid tissues including lung|
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Unknown. Unable to reduce HIV-1 infectivity in vitro.
Zhang, W., et al. PLoS ONE 3 (12), E3963 (2008) :Dang, Y., et al. J. Virol. 80(21):10522-10533(2006)Stenglein, M.D., et al. J. Biol. Chem. 281(25):16837-16841(2006)Conticello, S.G., et al. Mol. Biol. Evol. 22(2):367-377(2005)Harris, R.S., et al. Nat. Rev. Immunol. 4(11):868-877(2004)
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