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APOBEC3D Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q96AK3
Clone Names 110826026
Peptide ID 110826026
Additional Information
Other Names DNA dC->dU-editing enzyme APOBEC-3D, A3D, 354-, APOBEC3D
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Function DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination- independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double- stranded RNA. May inhibit the mobility of LTR and non-LTR retrotransposons.
Cellular Location Cytoplasm. Cytoplasm, P-body.
Tissue Location Expressed in lymphoid organs. Also detected in non-lymphoid tissues including lung
Research Areas
Citations (0)

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Unknown. Unable to reduce HIV-1 infectivity in vitro.


Zhang, W., et al. PLoS ONE 3 (12), E3963 (2008) :Dang, Y., et al. J. Virol. 80(21):10522-10533(2006)Stenglein, M.D., et al. J. Biol. Chem. 281(25):16837-16841(2006)Conticello, S.G., et al. Mol. Biol. Evol. 22(2):367-377(2005)Harris, R.S., et al. Nat. Rev. Immunol. 4(11):868-877(2004)

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$ 80.00
Cat# BP18763a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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