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APOBEC3D Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q96AK3 |
|---|---|
| Clone Names | 110826026 |
| Other Names | DNA dC->dU-editing enzyme APOBEC-3D, A3D, 354-, APOBEC3D |
|---|---|
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | APOBEC3D (HGNC:17354) |
|---|---|
| Function | DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase- dependent and -independent mechanisms (PubMed:16920826, PubMed:20062055, PubMed:21835787). Exhibits antiviral activity against HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single- strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA (PubMed:16920826). The resultant detrimental levels of mutations in the proviral genome, along with a deamination- independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Inhibits also the mobility of LTR and non-LTR retrotransposons (PubMed:27428332). |
| Cellular Location | Cytoplasm. Cytoplasm, P-body |
| Tissue Location | Expressed in lymphoid organs. Also detected in non- lymphoid tissues including lung. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Unknown. Unable to reduce HIV-1 infectivity in vitro.
References
Zhang, W., et al. PLoS ONE 3 (12), E3963 (2008) :Dang, Y., et al. J. Virol. 80(21):10522-10533(2006)Stenglein, M.D., et al. J. Biol. Chem. 281(25):16837-16841(2006)Conticello, S.G., et al. Mol. Biol. Evol. 22(2):367-377(2005)Harris, R.S., et al. Nat. Rev. Immunol. 4(11):868-877(2004)
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