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ATXN1L Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P0C7T5 |
|---|---|
| Clone Names | 110826038 |
| Gene ID | 342371 |
|---|---|
| Other Names | Ataxin-1-like, Brother of ataxin-1, Brother of ATXN1, ATXN1L, BOAT, BOAT1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ATXN1L |
|---|---|
| Synonyms | BOAT, BOAT1 |
| Function | Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ- mediated repression (PubMed:21475249). Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1). In concert with CIC and ATXN1, involved in brain development (By similarity). |
| Cellular Location | Nucleus. Cell projection, dendrite. Note=Forms nuclear foci. Colocalizes with NCOR2 and HDAC3. Distributed beyond the nucleus into the cell body and dendrites in Purkinje cells and in inferior olive cells |
| Tissue Location | Expressed in cerebellum and cerebral cortex. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
ATXN1L can suppress the cytotoxicity of ATXN1 in spinocerebellar ataxia type 1 (SCA1) (By similarity).
References
Bowman, A.B., et al. Nat. Genet. 39(3):373-379(2007)Mizutani, A., et al. EMBO J. 24(18):3339-3351(2005)Venter, J.C., et al. Science 291(5507):1304-1351(2001)
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