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KATNA1 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O75449
Clone Names 110826214
Peptide ID 110826214
Additional Information
Gene ID 11104
Other Names Katanin p60 ATPase-containing subunit A1 {ECO:0000255|HAMAP-Rule:MF_03023}, Katanin p60 subunit A1 {ECO:0000255|HAMAP-Rule:MF_03023}, 3643 {ECO:0000255|HAMAP-Rule:MF_03023}, p60 katanin {ECO:0000255|HAMAP-Rule:MF_03023}, KATNA1 {ECO:0000255|HAMAP-Rule:MF_03023}
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name KATNA1 {ECO:0000255|HAMAP-Rule:MF_03023}
Function Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
Cellular Location Cytoplasm. Midbody. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000255|HAMAP- Rule:MF_03023}. Cytoplasm, cytoskeleton, spindle pole Note=Predominantly cytoplasmic. Localized diffusely in the cytoplasm during the interphase. During metaphase is localized throughout the cell and more widely dispersed than the microtubules. In anaphase and telophase is localized at the midbody region. Also localized to the interphase centrosome and the mitotic spindle poles. Enhanced recruitment to the mitotic spindle poles requires microtubules and interaction with KATNB1
Research Areas
Citations (0)

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Microtubules, polymers of alpha and beta tubulin subunits,form the mitotic spindle of a dividing cell and help to organizemembranous organelles during interphase. Katanin is a heterodimerthat consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDaaccessory protein (p80 subunit B 1). The p60 subunit acts to severand disassemble microtubules, while the p80 subunit targets theenzyme to the centrosome. This gene encodes the p80 subunit. Thisprotein is a member of the AAA family of ATPases. [provided byRefSeq].


Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press :Iwaya, N., et al. J. Biol. Chem. 285(22):16822-16829(2010)Sudo, H., et al. Hum. Mol. Genet. 17(16):2524-2540(2008)Mungall, A.J., et al. Nature 425(6960):805-811(2003)Buster, D., et al. J. Cell. Sci. 115 (PT 5), 1083-1092 (2002) :

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$ 80.00
Cat# BP18785a
Availability: In Stock
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