|Other Names||Kazrin, KAZN, KAZ, KIAA1026|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the cornified envelope of keratinocytes. May be involved in the interplay between adherens junctions and desmosomes. The function in the nucleus is not known.|
|Cellular Location||Cytoplasm, cytoskeleton. Isoform 3: Cytoplasm. Cell junction, desmosome. Nucleus. Note=Observed at the apical plasma membrane of keratinocytes. Partially colocalizes with PPL and DP at desmosomes, and with PP at the interdesmosomal plasma membrane Colocalizes with cortical actin-based membrane structures|
|Tissue Location||Isoform 2, isoform 3 and isoform 4 are expressed in several cell lines including keratinocytes and bladder and epidermoid carcinoma (at protein level). Isoform 2, isoform 3 and isoform 4 are expressed in hair follicle and interfollicular epidermis (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
Component of the cornified envelope of keratinocytes. May be involved in the interplay between adherens junctions and desmosomes. The function in the nucleus is not known.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Nachat, R., et al. J. Cell. Sci. 122 (PT 22), 4035-4041 (2009) :Wang, Q., et al. Acta Biochim. Biophys. Sin. (Shanghai) 41(9):763-772(2009)Sevilla, L.M., et al. J. Cell. Sci. 121 (PT 21), 3561-3569 (2008) :Uhl, G.R., et al. Arch. Gen. Psychiatry 65(6):683-693(2008)
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