MCF2L Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O15068 |
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Clone Names | 110826252 |
Gene ID | 23263 |
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Other Names | Guanine nucleotide exchange factor DBS, DBL's big sister, MCF2-transforming sequence-like protein, MCF2L, KIAA0362 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | MCF2L |
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Synonyms | KIAA0362, OST {ECO:0000303|PubMed:151576 |
Function | Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signaling pathways (By similarity). Seems to lack activity with RAC1. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity). Isoform 5 activates CDC42 (PubMed:15157669). |
Cellular Location | [Isoform 5]: Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side Cytoplasm {ECO:0000250|UniProtKB:Q64096}. Cell membrane {ECO:0000250|UniProtKB:Q64096}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q64096}; Cytoplasmic side {ECO:0000250|UniProtKB:Q64096} |
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Background
Guanine nucleotide exchange factor that potentially links pathways that signal through RAC1, RHOA and CDC42. Catalyzes guanine nucleotide exchange on RHOA and CDC42 and interacts specifically with the GTP-bound form of RAC1, suggesting that it functions as an effector of RAC1. May also participate in axonal transport in the brain. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity). Isoform 5 activates CDC42.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Takefuji, M., et al. J. Hum. Genet. 55(1):42-49(2010)Ieguchi, K., et al. J. Biol. Chem. 282(32):23296-23305(2007)Yang, Q., et al. BMC Med. Genet. 8 SUPPL 1, S12 (2007) :Kostenko, E.V., et al. J. Biol. Chem. 280(4):2807-2817(2005)
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