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MCF2L Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession O15068
Clone Names 110826252
Peptide ID 110826252
Additional Information
Gene ID 23263
Other Names Guanine nucleotide exchange factor DBS, DBL's big sister, MCF2-transforming sequence-like protein, MCF2L, KIAA0362
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MCF2L
Synonyms KIAA0362, OST {ECO:0000303|PubMed:151576
Function Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signaling pathways (By similarity). Seems to lack activity with RAC1. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity). Isoform 5 activates CDC42 (PubMed:15157669).
Cellular Location Isoform 5: Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side Cytoplasm {ECO:0000250|UniProtKB:Q64096}. Cell membrane {ECO:0000250|UniProtKB:Q64096}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q64096}; Cytoplasmic side {ECO:0000250|UniProtKB:Q64096}
Research Areas
Citations (0)

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Background

Guanine nucleotide exchange factor that potentially links pathways that signal through RAC1, RHOA and CDC42. Catalyzes guanine nucleotide exchange on RHOA and CDC42 and interacts specifically with the GTP-bound form of RAC1, suggesting that it functions as an effector of RAC1. May also participate in axonal transport in the brain. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity). Isoform 5 activates CDC42.

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Takefuji, M., et al. J. Hum. Genet. 55(1):42-49(2010)Ieguchi, K., et al. J. Biol. Chem. 282(32):23296-23305(2007)Yang, Q., et al. BMC Med. Genet. 8 SUPPL 1, S12 (2007) :Kostenko, E.V., et al. J. Biol. Chem. 280(4):2807-2817(2005)

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$ 80.00
Cat# BP18793b
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