|Other Names||MMS19 nucleotide excision repair protein homolog, hMMS19, MET18 homolog, MMS19-like protein, MMS19, MMS19L|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery.|
|Cellular Location||Nucleus. Cytoplasm, cytoskeleton, spindle.|
|Tissue Location||Ubiquitously expressed with higher expression in testis.|
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MMS19 may play a role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription by interacting with ERCC2/XPD and ERCC3/XPB helicases, both subunits of NER-transcription factor TFIIH. May also function as a transcriptional coactivator of estrogen receptor (ER). May be involved in regulation of ER activity by bridging TFIIH with ER or may facilitate TFIIH-mediated phosphorylation of ER in specific promoters and cell types.
Ito, S., et al. Mol. Cell 39(4):632-640(2010)Briggs, F.B., et al. Am. J. Epidemiol. 172(2):217-224(2010)McWilliams, R.R., et al. Cancer Epidemiol. Biomarkers Prev. 18(4):1295-1302(2009)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Hatfield, M.D., et al. DNA Repair (Amst.) 5(8):914-924(2006)
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