|Other Names||Ileal sodium/bile acid cotransporter, Apical sodium-dependent bile acid transporter, ASBT, Ileal Na(+)/bile acid cotransporter, Ileal sodium-dependent bile acid transporter, IBAT, ISBT, Na(+)-dependent ileal bile acid transporter, Sodium/taurocholate cotransporting polypeptide, ileal, Solute carrier family 10 member 2, SLC10A2, ASBT, ISBT, NTCP2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||ASBT, ISBT, NTCP2|
|Function||Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
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This gene encodes a sodium/bile acid cotransporter. Thistransporter is the primary mechanism for uptake of intestinal bileacids by apical cells in the distal ileum. Bile acids are thecatabolic product of cholesterol metabolism, so this protein isalso critical for cholesterol homeostasis. Mutations in this genecause primary bile acid malabsorption (PBAM); muatations in thisgene may also be associated with other diseases of the liver andintestines, such as familial hypertriglyceridemia (FHTG). [providedby RefSeq].
Halpern, M.D., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 299 (3), G623-G631 (2010) :Zheng, X., et al. Int J Pharm 396 (1-2), 111-118 (2010) :Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)Roberts, K.E., et al. Gastroenterology 139(1):130-139(2010)Edenberg, H.J., et al. Alcohol. Clin. Exp. Res. 34(5):840-852(2010)
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