CRADD Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P78560 |
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Clone Names | 100427317 |
Gene ID | 8738 |
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Other Names | Death domain-containing protein CRADD, Caspase and RIP adapter with death domain, RIP-associated protein with a death domain, CRADD, RAIDD |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | CRADD |
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Synonyms | RAIDD |
Function | Adapter protein that associates with PIDD1 and the caspase CASP2 to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis (PubMed:9044836, PubMed:15073321, PubMed:16652156, PubMed:17159900, PubMed:17289572). Also recruits CASP2 to the TNFR-1 signaling complex through its interaction with RIPK1 and TRADD and may play a role in the tumor necrosis factor-mediated signaling pathway (PubMed:8985253). |
Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:O88843}. Nucleus {ECO:0000250|UniProtKB:O88843} |
Tissue Location | Constitutively expressed in most tissues, with particularly high expression in adult heart, testis, liver, skeletal muscle, fetal liver and kidney. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a death domain(CARD/DD)-containing protein and has been shown to induce cellapoptosis. Through its CARD domain, this protein interacts with,and thus recruits, caspase 2/ICH1 to the cell death signaltransduction complex that includes tumor necrosis factor receptor 1(TNFR1A), RIPK1/RIP kinase, and numbers of other CARDdomain-containing proteins.
References
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Jang, T.H., et al. Biochim. Biophys. Acta 1804(7):1557-1563(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Zhao, J., et al. BMC Med. Genet. 11, 96 (2010) :Heikaus, S., et al. Cell. Oncol. 32 (1-2), 29-42 (2010) :
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