|Other Names||Death domain-containing protein CRADD, Caspase and RIP adapter with death domain, RIP-associated protein with a death domain, CRADD, RAIDD|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex.|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Constitutively expressed in most tissues, with particularly high expression in adult heart, testis, liver, skeletal muscle, fetal liver and kidney|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a death domain(CARD/DD)-containing protein and has been shown to induce cellapoptosis. Through its CARD domain, this protein interacts with,and thus recruits, caspase 2/ICH1 to the cell death signaltransduction complex that includes tumor necrosis factor receptor 1(TNFR1A), RIPK1/RIP kinase, and numbers of other CARDdomain-containing proteins.
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Jang, T.H., et al. Biochim. Biophys. Acta 1804(7):1557-1563(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Zhao, J., et al. BMC Med. Genet. 11, 96 (2010) :Heikaus, S., et al. Cell. Oncol. 32 (1-2), 29-42 (2010) :
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.