|Other Names||Death domain-containing protein CRADD, Caspase and RIP adapter with death domain, RIP-associated protein with a death domain, CRADD, RAIDD|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex.|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Constitutively expressed in most tissues, with particularly high expression in adult heart, testis, liver, skeletal muscle, fetal liver and kidney|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a death domain(CARD/DD)-containing protein and has been shown to induce cellapoptosis. Through its CARD domain, this protein interacts with,and thus recruits, caspase 2/ICH1 to the cell death signaltransduction complex that includes tumor necrosis factor receptor 1(TNFR1A), RIPK1/RIP kinase, and numbers of other CARDdomain-containing proteins.
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Jang, T.H., et al. Biochim. Biophys. Acta 1804(7):1557-1563(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Zhao, J., et al. BMC Med. Genet. 11, 96 (2010) :Heikaus, S., et al. Cell. Oncol. 32 (1-2), 29-42 (2010) :
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