|Other Names||Heat shock factor protein 2, HSF 2, Heat shock transcription factor 2, HSTF 2, HSF2, HSTF2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked.|
|Cellular Location||Cytoplasm. Nucleus. Note=Cytoplasmic during normal growth and moves to the nucleus upon activation|
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Provided below are standard protocols that you may find useful for product applications.
HSF2, as well as the related gene HSF1, encodes a proteinthat binds specifically to the heat-shock element and has homologyto HSFs of other species. Heat shock transcription factors activateheat-shock response genes under conditions of heat or otherstresses. Although the names HSF1 and HSF2 were chosen forhistorical reasons, these peptides should be referred to asheat-shock transcription factors.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Xing, H., et al. Cell Stress Chaperones 15(3):301-308(2010)Sandqvist, A., et al. Mol. Biol. Cell 20(5):1340-1347(2009)Tateishi, Y., et al. J. Biol. Chem. 284(4):2435-2447(2009)Vieira, A.R., et al. Genet. Med. 10(9):668-674(2008)
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