|Other Names||Neuropeptide Y receptor type 1, NPY1-R, NPY1R, NPYR, NPYY1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
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Neuropeptide Y (NPY; MIM 162640) is one of the mostabundant neuropeptides in the mammalian nervous system and exhibitsa diverse range of important physiologic activities, includingeffects on psychomotor activity, food intake, regulation of centralendocrine secretion, and potent vasoactive effects on thecardiovascular system. Two major subtypes of NPY (Y1 and Y2) havebeen defined by pharmacologic criteria. NPY receptors, such asNPY1R, have been identified in a variety of tissues, includingbrain, spleen, small intestine, kidney, testis, placenta, andaortic smooth muscle (Herzog et al., 1992 [PubMed1321422]).
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Kim, H.Y., et al. BMB Rep 43(8):547-553(2010)Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :Naukkarinen, J., et al. PLoS Genet. 6 (6), E1000976 (2010) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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