|Other Names||Double-stranded RNA-binding protein Staufen homolog 1, STAU1, STAU|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site.|
|Cellular Location||Cytoplasm. Rough endoplasmic reticulum Note=Localizes exclusively with the rough reticulum endoplasmic (RER)|
|Tissue Location||Widely expressed. Expressed in brain, pancreas, heart, skeletal muscles, liver, lung, kidney and placenta|
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Staufen is a member of the family of double-stranded RNA(dsRNA)-binding proteins involved in the transport and/orlocalization of mRNAs to different subcellular compartments and/ororganelles. These proteins are characterized by the presence ofmultiple dsRNA-binding domains which are required to bind RNAshaving double-stranded secondary structures. The human homologue ofstaufen encoded by STAU, in addition contains a microtubule-binding domain similar to that of microtubule-associated protein1B, and binds tubulin. The STAU gene product has been shown to bepresent in the cytoplasm in association with the rough endoplasmicreticulum (RER), implicating this protein in the transport of mRNAvia the microtubule network to the RER, the site of translation.Five transcript variants resulting from alternative splicing ofSTAU gene and encoding three isoforms have been described. Three ofthese variants encode the same isoform, however, differ in their5'UTR.
de Lucas, S., et al. J. Virol. 84(15):7603-7612(2010)Martel, C., et al. RNA 16(3):585-597(2010)Abrahamyan, L.G., et al. J. Cell. Sci. 123 (PT 3), 369-383 (2010) :Milev, M.P., et al. Retrovirology 7, 41 (2010) :Weidensdorfer, D., et al. RNA 15(1):104-115(2009)
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