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GINS2 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9Y248 |
|---|---|
| Clone Names | 100603099 |
| Gene ID | 51659 |
|---|---|
| Other Names | DNA replication complex GINS protein PSF2, GINS complex subunit 2, GINS2, PSF2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | GINS2 (HGNC:24575) |
|---|---|
| Synonyms | PSF2 |
| Function | Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks (PubMed:17417653). GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). |
| Cellular Location | Nucleus. Chromosome. Note=Associates with chromatin |
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Provided below are standard protocols that you may find useful for product applications.
Background
The yeast heterotetrameric GINS complex is made up of Sld5(GINS4; MIM 610611), Psf1 (GINS1; MIM 610608), Psf2, and Psf3(GINS3; MIM 610610). The formation of this complex is essential forthe initiation of DNA replication in yeast and Xenopus egg extracts(Ueno et al., 2005 [PubMed 16287864]). See GINS1 for additionalinformation about the GINS complex.
References
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)Matsuoka, S., et al. Science 316(5828):1160-1166(2007)Lamesch, P., et al. Genomics 89(3):307-315(2007)Takayama, Y., et al. Genes Dev. 17(9):1153-1165(2003)
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