|Other Names||DNA replication complex GINS protein PSF2, GINS complex subunit 2, GINS2, PSF2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single- stranded DNA.|
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Provided below are standard protocols that you may find useful for product applications.
The yeast heterotetrameric GINS complex is made up of Sld5(GINS4; MIM 610611), Psf1 (GINS1; MIM 610608), Psf2, and Psf3(GINS3; MIM 610610). The formation of this complex is essential forthe initiation of DNA replication in yeast and Xenopus egg extracts(Ueno et al., 2005 [PubMed 16287864]). See GINS1 for additionalinformation about the GINS complex.
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)Matsuoka, S., et al. Science 316(5828):1160-1166(2007)Lamesch, P., et al. Genomics 89(3):307-315(2007)Takayama, Y., et al. Genes Dev. 17(9):1153-1165(2003)
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