|Other Names||G-protein coupled receptor family C group 6 member A, hGPRC6A, G-protein coupled receptor GPCR33, hGPCR33, GPRC6A|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+). Activated by extracellular calcium and osteocalin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinates nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalents ions and its responsiveness to anabolic steroids.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Isoform 1 is expressed at high level in brain, skeletal muscle, testis, bone, calvaria, osteoblasts and leukocytes. Expressed at intermediate level in liver, heart, kidney and spleen. Expressed at low level in lung, pancreas, placenta and ovary. Not detected in thymus, prostate, small intestine, tongue and colon. Isoform 1 and isoform 2 are expressed in kidney at the same level. Isoform 2 is expressed at lower level than isoform 1 in the other tissues|
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Provided below are standard protocols that you may find useful for product applications.
Members of family C of the G protein-coupled receptor(GPCR) superfamily, such as GPRC6A, are characterized by anevolutionarily conserved amino acid-sensing motif linked to anintramembranous 7-transmembrane loop region. Several members ofGPCR family C, including GPRC6A, also have a long N-terminal domain(summary by Pi et al., 2005 [PubMed 16199532]).
Giroux, S., et al. Bone 47(5):975-981(2010)Takata, R., et al. Nat. Genet. 42(9):751-754(2010)Pi, M., et al. J. Bone Miner. Res. 25(5):1092-1102(2010)Dowal, L., et al. J. Biol. Chem. 281(33):23999-24014(2006)Pi, M., et al. J. Biol. Chem. 280(48):40201-40209(2005)
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