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STX4 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q12846 |
|---|---|
| Clone Names | 100617283 |
| Gene ID | 6810 |
|---|---|
| Other Names | Syntaxin-4, Renal carcinoma antigen NY-REN-31, STX4, STX4A |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | STX4 |
|---|---|
| Synonyms | STX4A |
| Function | Plasma membrane t-SNARE that mediates docking of transport vesicles (By similarity). Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane (By similarity). In neurons, recruited at neurite tips to membrane domains rich in the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) which promotes neurite tip surface expression of the dopamine transporter SLC6A3/DAT by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane (By similarity). Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes and in docking of synaptic vesicles at presynaptic active zones (By similarity). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q08850}; Single-pass type IV membrane protein. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q08850}. Note=Localizes to neurite tips in neuronal cells. {ECO:0000250|UniProtKB:Q08850} |
| Tissue Location | Expressed in neutrophils and neutrophil- differentiated HL-60 cells. Expression in neutrophils increases with differentiation. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones.
References
Evesson, F.J., et al. J. Biol. Chem. 285(37):28529-28539(2010)Kennedy, M.J., et al. Cell 141(3):524-535(2010)Brochetta, C., et al. Biochim. Biophys. Acta 1783(10):1781-1791(2008)Cooper, G.M., et al. Blood 112(4):1022-1027(2008)Low, S.H., et al. Mol. Biol. Cell 17(2):977-989(2006)
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