|Other Names||Interleukin-15 receptor subunit alpha, IL-15 receptor subunit alpha, IL-15R-alpha, IL-15RA, CD215, Soluble interleukin-15 receptor subunit alpha, sIL-15 receptor subunit alpha, sIL-15R-alpha, sIL-15RA, IL15RA|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Expression of different isoforms may alter or interfere with signal transduction. Isoform 5, isoform 6, isoform 7 and isoform 8 do not bind IL15. Signal transduction involves SYK.|
|Cellular Location||Membrane; Single-pass type I membrane protein Nucleus membrane; Single-pass type I membrane protein. Note=Mainly found associated with the nuclear membrane Isoform 6: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane Isoform 8: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane|
|Tissue Location||Isoform 1, isoform 3, isoform 4, isoform 5, isoform 6, isoform 7, isoform 8 and isoform 9 are widely expressed. Expressed in fetal brain with higher expression in the hippocampus and cerebellum than in cortex and thalamus. Higher levels of soluble sIL-15RA form in comparison with membrane-bound forms is present in all brain structures|
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This gene encodes a cytokine receptor that specificallybinds interleukin 15 (IL15) with high affinity. The receptors ofIL15 and IL2 share two subunits, IL2R beta and IL2R gamma. Thisforms the basis of many overlapping biological activities of IL15and IL2. The protein encoded by this gene is structurally relatedto IL2R alpha, an additional IL2-specific alpha subunit necessaryfor high affinity IL2 binding. Unlike IL2RA, IL15RA is capable ofbinding IL15 with high affinity independent of other subunits,which suggests distinct roles between IL15 and IL2. This receptoris reported to enhance cell proliferation and expression ofapoptosis inhibitor BCL2L1/BCL2-XL and BCL2. Multiple alternativelyspliced transcript variants of this gene have been reported.
Wu, Z., et al. J Mol Cell Biol 2(4):217-222(2010)Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010)Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :Bergamaschi, C., et al. J. Immunol. 183(5):3064-3072(2009)
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