SLC9A1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P19634 |
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Clone Names | 100507202 |
Gene ID | 6548 |
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Other Names | Sodium/hydrogen exchanger 1, APNH, Na(+)/H(+) antiporter, amiloride-sensitive, Na(+)/H(+) exchanger 1, NHE-1, Solute carrier family 9 member 1, SLC9A1, APNH1, NHE1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | SLC9A1 (HGNC:11071) |
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Function | Electroneutral Na(+) /H(+) antiporter that extrudes Na(+) in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism (PubMed:7110335, PubMed:7603840, PubMed:11532004, PubMed:11350981, PubMed:15035633, PubMed:14680478, PubMed:17073455, PubMed:22020933, PubMed:27650500, PubMed:15677483, PubMed:32130622, PubMed:17493937). Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry (By similarity). Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival (PubMed:8901634, PubMed:12947095, PubMed:15096511, PubMed:22020933). In addition, can transport lithium Li(+) and functions also as a Na(+)/Li(+) antiporter (PubMed:7603840). SLC9A1 also functions in membrane anchoring and organization of scaffolding complexes that coordinate signaling inputs (PubMed:15096511). |
Cellular Location | Cell membrane; Multi-pass membrane protein. Basolateral cell membrane {ECO:0000250|UniProtKB:P48762}; Multi-pass membrane protein. Note=Localized basolaterally in every epithelial cell, except in the choroid plexus where SLC9A1 is expressed luminally. |
Tissue Location | Kidney and intestine. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The Na+/H+ antiporter (SLC9A1) is a ubiquitousmembrane-bound enzyme involved in pH regulation of vertebratecells. It is specifically inhibited by the diuretic drug amilorideand activated by a variety of signals including growth factors,mitogens, neurotransmitters, tumor promoters, and others (Mattei etal., 1988 [PubMed 2846238]).
References
Busco, G., et al. FASEB J. 24(10):3903-3915(2010)Yang, X., et al. Cancer Lett. 295(2):198-204(2010)Lauritzen, G., et al. Exp. Cell Res. 316(15):2538-2553(2010)Rotte, A., et al. Biochem. Biophys. Res. Commun. 398(4):677-682(2010)Holthouser, K.A., et al. Am. J. Physiol. Renal Physiol. 299 (1), F77-F90 (2010) :
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