|Other Names||Sodium/hydrogen exchanger 1, APNH, Na(+)/H(+) antiporter, amiloride-sensitive, Na(+)/H(+) exchanger 1, NHE-1, Solute carrier family 9 member 1, SLC9A1, APNH1, NHE1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.|
|Cellular Location||Membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein Note=Colocalizes with CHP1 at the reticulum endoplasmic (By similarity). Colocalizes with CHP1 and CHP2 at the plasma membrane.|
|Tissue Location||Kidney and intestine.|
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Provided below are standard protocols that you may find useful for product applications.
The Na+/H+ antiporter (SLC9A1) is a ubiquitousmembrane-bound enzyme involved in pH regulation of vertebratecells. It is specifically inhibited by the diuretic drug amilorideand activated by a variety of signals including growth factors,mitogens, neurotransmitters, tumor promoters, and others (Mattei etal., 1988 [PubMed 2846238]).
Busco, G., et al. FASEB J. 24(10):3903-3915(2010)Yang, X., et al. Cancer Lett. 295(2):198-204(2010)Lauritzen, G., et al. Exp. Cell Res. 316(15):2538-2553(2010)Rotte, A., et al. Biochem. Biophys. Res. Commun. 398(4):677-682(2010)Holthouser, K.A., et al. Am. J. Physiol. Renal Physiol. 299 (1), F77-F90 (2010) :
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