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SLC9A1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P19634 |
|---|---|
| Clone Names | 100507202 |
| Gene ID | 6548 |
|---|---|
| Other Names | Sodium/hydrogen exchanger 1, APNH, Na(+)/H(+) antiporter, amiloride-sensitive, Na(+)/H(+) exchanger 1, NHE-1, Solute carrier family 9 member 1, SLC9A1, APNH1, NHE1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SLC9A1 (HGNC:11071) |
|---|---|
| Function | Electroneutral Na(+) /H(+) antiporter that extrudes Na(+) in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism (PubMed:7110335, PubMed:7603840, PubMed:11532004, PubMed:11350981, PubMed:15035633, PubMed:14680478, PubMed:17073455, PubMed:22020933, PubMed:27650500, PubMed:15677483, PubMed:32130622, PubMed:17493937). Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry (By similarity). Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival (PubMed:8901634, PubMed:12947095, PubMed:15096511, PubMed:22020933). In addition, can transport lithium Li(+) and functions also as a Na(+)/Li(+) antiporter (PubMed:7603840). SLC9A1 also functions in membrane anchoring and organization of scaffolding complexes that coordinate signaling inputs (PubMed:15096511). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Basolateral cell membrane {ECO:0000250|UniProtKB:P48762}; Multi-pass membrane protein. Note=Localized basolaterally in every epithelial cell, except in the choroid plexus where SLC9A1 is expressed luminally. |
| Tissue Location | Kidney and intestine. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The Na+/H+ antiporter (SLC9A1) is a ubiquitousmembrane-bound enzyme involved in pH regulation of vertebratecells. It is specifically inhibited by the diuretic drug amilorideand activated by a variety of signals including growth factors,mitogens, neurotransmitters, tumor promoters, and others (Mattei etal., 1988 [PubMed 2846238]).
References
Busco, G., et al. FASEB J. 24(10):3903-3915(2010)Yang, X., et al. Cancer Lett. 295(2):198-204(2010)Lauritzen, G., et al. Exp. Cell Res. 316(15):2538-2553(2010)Rotte, A., et al. Biochem. Biophys. Res. Commun. 398(4):677-682(2010)Holthouser, K.A., et al. Am. J. Physiol. Renal Physiol. 299 (1), F77-F90 (2010) :
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