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PCBP1 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q15365
Clone Names 100617295
Peptide ID 100617295
Additional Information
Gene ID 5093
Other Names Poly(rC)-binding protein 1, Alpha-CP1, Heterogeneous nuclear ribonucleoprotein E1, hnRNP E1, Nucleic acid-binding protein SUB23, PCBP1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PCBP1
Function Single-stranded nucleic acid binding protein that binds preferentially to oligo dC.
Cellular Location Nucleus. Cytoplasm. Note=Loosely bound in the nucleus. May shuttle between the nucleus and the cytoplasm
Tissue Location Abundantly expressed in skeletal muscle, thymus and peripheral blood leukocytes while a lower expression is observed in prostate, spleen, testis, ovary, small intestine, heart, liver, adrenal and thyroid glands
Research Areas
Citations (0)

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This intronless gene is thought to have been generated byretrotransposition of a fully processed PCBP-2 mRNA. This gene andPCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to havearisen as a result of duplication events of entire genes. Theprotein encoded by this gene appears to be multifunctional. Italong with PCBP-2 and hnRNPK corresponds to the major cellularpoly(rC)-binding protein. It contains three K-homologous (KH)domains which may be involved in RNA binding. This encoded proteintogether with PCBP-2 also functions as translational coactivatorsof poliovirus RNA via a sequence-specific interaction withstem-loop IV of the IRES and promote poliovirus RNA replication bybinding to its 5'-terminal cloverleaf structure. It has also beenimplicated in translational control of the 15-lipoxygenase mRNA,human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA.The encoded protein is also suggested to play a part in formationof a sequence-specific alpha-globin mRNP complex which isassociated with alpha-globin mRNA stability.


Cloke, B., et al. Endocrinology 151(8):3954-3964(2010)Wang, H., et al. Cancer Cell 18(1):52-62(2010)Zhang, T., et al. Mol. Cancer 9, 72 (2010) :Waggoner, S.A., et al. J. Biol. Chem. 284(14):9039-9049(2009)Huo, L.R., et al. Biochim. Biophys. Acta 1784(11):1524-1533(2008)

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$ 80.00
Cat# BP18827c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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