|Other Names||Transcription initiation factor TFIID subunit 10, STAF28, Transcription initiation factor TFIID 30 kDa subunit, TAF(II)30, TAFII-30, TAFII30, TAF10, TAF2A, TAF2H, TAFII30|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||TAF2A, TAF2H, TAFII30|
|Function||TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.|
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Initiation of transcription by RNA polymerase II requiresthe activities of more than 70 polypeptides. The protein thatcoordinates these activities is transcription factor IID (TFIID),which binds to the core promoter to position the polymeraseproperly, serves as the scaffold for assembly of the remainder ofthe transcription complex, and acts as a channel for regulatorysignals. TFIID is composed of the TATA-binding protein (TBP) and agroup of evolutionarily conserved proteins known as TBP-associatedfactors or TAFs. TAFs may participate in basal transcription, serveas coactivators, function in promoter recognition or modify generaltranscription factors (GTFs) to facilitate complex assembly andtranscription initiation. This gene encodes one of the smallsubunits of TFIID that is associated with a subset of TFIIDcomplexes. Studies with human and mammalian cells have shown thatthis subunit is required for transcriptional activation by theestrogen receptor, for progression through the cell cycle, and mayalso be required for certain cellular differentiation programs.
Egloff, S., et al. J. Biol. Chem. 285(27):20564-20569(2010)Ma, Y., et al. J. Biol. Chem. 285(13):9813-9822(2010)Zhao, Y., et al. Mol. Cell 29(1):92-101(2008)Hao, H., et al. Oncogene 26(57):7872-7884(2007)Couture, J.F., et al. Nat. Struct. Mol. Biol. 13(2):140-146(2006)
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