|Other Names||Ral guanine nucleotide dissociation stimulator, RalGDS, Ral guanine nucleotide exchange factor, RalGEF, RALGDS, KIAA1308, RGF|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Stimulates the dissociation of GDP from the Ras-related RalA and RalB GTPases which allows GTP binding and activation of the GTPases. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap.|
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Provided below are standard protocols that you may find useful for product applications.
Guanine nucleotide dissociation stimulators (GDSs, orexchange factors), such as RALGDS, are effectors of Ras-relatedGTPases (see MIM 190020) that participate in signaling for avariety of cellular processes.
Fuentes, G., et al. Trends Biochem. Sci. 34(11):533-539(2009)Maehama, T., et al. J. Biol. Chem. 283(50):35053-35059(2008)Rondaij, M.G., et al. Blood 112(1):56-63(2008)Omholt, K., et al. Melanoma Res. 17(6):410-412(2007)Yin, J., et al. Mol. Cell. Biol. 27(21):7538-7550(2007)
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