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RALGDS Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q12967
Clone Names 100617311
Additional Information
Gene ID 5900
Other Names Ral guanine nucleotide dissociation stimulator, RalGDS, Ral guanine nucleotide exchange factor, RalGEF, RALGDS, KIAA1308, RGF
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name RALGDS
Synonyms KIAA1308, RGF
Function Functions as a guanine nucleotide exchange factor (GEF) activating either RalA or RalB GTPases and plays an important role in intracellular transport. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap (By similarity). During bacterial clearance, recognizes 'Lys-33'-linked polyubiquitinated TRAF3 and subsequently mediates assembly of the exocyst complex (PubMed:27438768).
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:Q03385}. Nucleus {ECO:0000250|UniProtKB:Q03385}. Note=Localizes mainly in the peripheral region of the cytoplasmic membrane in oocytes and in preimplantation embryos until the 8-cell stage. Between the late 1-cell and the early 2-cell stages, nuclear localization becomes stronger. After the 4-cell stage, not detected in the nucleus. {ECO:0000250|UniProtKB:Q03385}
Research Areas
Citations (0)
citation

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Background

Guanine nucleotide dissociation stimulators (GDSs, orexchange factors), such as RALGDS, are effectors of Ras-relatedGTPases (see MIM 190020) that participate in signaling for avariety of cellular processes.

References

Fuentes, G., et al. Trends Biochem. Sci. 34(11):533-539(2009)Maehama, T., et al. J. Biol. Chem. 283(50):35053-35059(2008)Rondaij, M.G., et al. Blood 112(1):56-63(2008)Omholt, K., et al. Melanoma Res. 17(6):410-412(2007)Yin, J., et al. Mol. Cell. Biol. 27(21):7538-7550(2007)

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$ 277.78
Cat# BP18831c
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