|Other Names||Na(+)/H(+) exchange regulatory cofactor NHE-RF2, NHERF-2, NHE3 kinase A regulatory protein E3KARP, SRY-interacting protein 1, SIP-1, Sodium-hydrogen exchanger regulatory factor 2, Solute carrier family 9 isoform A3 regulatory factor 2, Tyrosine kinase activator protein 1, TKA-1, SLC9A3R2, NHERF2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3 (PubMed:18829453). May also act as scaffold protein in the nucleus.|
|Cellular Location||Endomembrane system; Peripheral membrane protein. Nucleus. Apical cell membrane Note=Localizes with EZR and PODXL at the apical cell membrane of glomerular epithelium cells and the sides of the food processes (By similarity). Nuclear, in a punctate pattern.|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
NHE3 (SLC9A3; MIM 182307) is a sodium/hydrogen exchangerin the brush border membrane of the proximal tubule, smallintestine, and colon that plays a major role in transepithelialsodium absorption. SLC9A3R2, as well as SLC9A3R1 (MIM 604990) andprotein kinase A phosphorylation, may play a role in NHE3regulation.
Padanyi, R., et al. J. Biol. Chem. 285(41):31704-31712(2010)Wang, B., et al. J. Biol. Chem. 285(35):26976-26986(2010)Arnaud, C., et al. FEBS Lett. 583(14):2326-2332(2009)Huang, F.D., et al. Placenta 30(2):187-194(2009)Theisen, C.S., et al. Mol. Biol. Cell 18(4):1220-1232(2007)
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