|Other Names||Fibroblast growth factor receptor substrate 2, FGFR substrate 2, FGFR-signaling adaptor SNT, Suc1-associated neurotrophic factor target 1, SNT-1, FRS2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3- kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.|
|Cellular Location||Endomembrane system. Note=Cytoplasmic, membrane-bound|
|Tissue Location||Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis|
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Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.
Zhou, W., et al. Cell Res. 19(10):1165-1177(2009)Cha, J.Y., et al. J. Biol. Chem. 284(10):6227-6240(2009)Li, M., et al. J. Dermatol. Sci. 53(3):182-191(2009)Turner, S.T., et al. Hypertension 52(2):359-365(2008)Gudbjartsson, D.F., et al. Nat. Genet. 40(5):609-615(2008)
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