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FRS2 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8WU20 |
|---|---|
| Clone Names | 100617317 |
| Gene ID | 10818 |
|---|---|
| Other Names | Fibroblast growth factor receptor substrate 2, FGFR substrate 2, FGFR-signaling adaptor SNT, Suc1-associated neurotrophic factor target 1, SNT-1, FRS2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | FRS2 |
|---|---|
| Function | Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. |
| Cellular Location | Endomembrane system. Note=Cytoplasmic, membrane- bound |
| Tissue Location | Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.
References
Zhou, W., et al. Cell Res. 19(10):1165-1177(2009)Cha, J.Y., et al. J. Biol. Chem. 284(10):6227-6240(2009)Li, M., et al. J. Dermatol. Sci. 53(3):182-191(2009)Turner, S.T., et al. Hypertension 52(2):359-365(2008)Gudbjartsson, D.F., et al. Nat. Genet. 40(5):609-615(2008)
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