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TREM1 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9NP99
Clone Names 100623001
Peptide ID 100623001
Additional Information
Gene ID 54210
Other Names Triggering receptor expressed on myeloid cells 1, TREM-1, Triggering receptor expressed on monocytes 1, CD354, TREM1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TREM1
Function Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock.
Cellular Location Isoform 1: Cell membrane; Single-pass type I membrane protein
Tissue Location Highly expressed in adult liver, lung and spleen than in corresponding fetal tissue. Also expressed in the lymph node, placenta, spinal cord and heart tissues. Expression is more elevated in peripheral blood leukocytes than in the bone marrow and in normal cells than malignant cells. Expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes Strongly expressed in acute inflammatory lesions caused by bacteria and fungi. Isoform 2 was detected in the lung, liver and mature monocytes.
Research Areas
Citations (0)

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Monocyte/macrophage- and neutrophil-mediated inflammatoryresponses can be stimulated through a variety of receptors,including G protein-linked 7-transmembrane receptors (e.g., FPR1;MIM 136537), Fc receptors (see MIM 146790), CD14 (MIM 158120) andToll-like receptors (e.g., TLR4; MIM 603030), and cytokinereceptors (e.g., IFNGR1; MIM 107470). Engagement of these receptorscan also prime myeloid cells to respond to other stimuli. Myeloidcells express receptors belonging to the Ig superfamily, such asTREM1, or to the C-type lectin superfamily. Depending on theirtransmembrane and cytoplasmic sequence structure, these receptorshave either activating (e.g., KIR2DS1; MIM 604952) or inhibitoryfunctions (e.g., KIR2DL1; MIM 604936).


Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Tomita, H., et al. J. Rheumatol. 37(4):787-791(2010)Haselmayer, P., et al. J Innate Immun 1(6):582-591(2009)Kim, J., et al. Clin. Exp. Rheumatol. 27(5):773-778(2009)

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$ 80.00
Cat# BP18834b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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