|Other Names||Triggering receptor expressed on myeloid cells 1, TREM-1, Triggering receptor expressed on monocytes 1, CD354, TREM1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock.|
|Cellular Location||Isoform 1: Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Highly expressed in adult liver, lung and spleen than in corresponding fetal tissue. Also expressed in the lymph node, placenta, spinal cord and heart tissues. Expression is more elevated in peripheral blood leukocytes than in the bone marrow and in normal cells than malignant cells. Expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes Strongly expressed in acute inflammatory lesions caused by bacteria and fungi. Isoform 2 was detected in the lung, liver and mature monocytes.|
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Provided below are standard protocols that you may find useful for product applications.
Monocyte/macrophage- and neutrophil-mediated inflammatoryresponses can be stimulated through a variety of receptors,including G protein-linked 7-transmembrane receptors (e.g., FPR1;MIM 136537), Fc receptors (see MIM 146790), CD14 (MIM 158120) andToll-like receptors (e.g., TLR4; MIM 603030), and cytokinereceptors (e.g., IFNGR1; MIM 107470). Engagement of these receptorscan also prime myeloid cells to respond to other stimuli. Myeloidcells express receptors belonging to the Ig superfamily, such asTREM1, or to the C-type lectin superfamily. Depending on theirtransmembrane and cytoplasmic sequence structure, these receptorshave either activating (e.g., KIR2DS1; MIM 604952) or inhibitoryfunctions (e.g., KIR2DL1; MIM 604936).
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Tomita, H., et al. J. Rheumatol. 37(4):787-791(2010)Haselmayer, P., et al. J Innate Immun 1(6):582-591(2009)Kim, J., et al. Clin. Exp. Rheumatol. 27(5):773-778(2009)
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