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TREM1 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9NP99 |
|---|---|
| Clone Names | 100623001 |
| Gene ID | 54210 |
|---|---|
| Other Names | Triggering receptor expressed on myeloid cells 1, TREM-1, Triggering receptor expressed on monocytes 1, CD354, TREM1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | TREM1 |
|---|---|
| Function | [Isoform 1]: Cell surface receptor that plays important roles in innate and adaptive immunity by amplifying inflammatory responses (PubMed:10799849, PubMed:21393102). Upon activation by various ligands such as PGLYRP1, HMGB1 or HSP70, multimerizes and forms a complex with transmembrane adapter TYROBP/DAP12 (PubMed:25595774, PubMed:17568691, PubMed:29568119). In turn, initiates a SYK-mediated cascade of tyrosine phosphorylation, activating multiple downstream mediators such as BTK, MAPK1, MAPK3 or phospholipase C-gamma (PubMed:21659545, PubMed:14656437). This cascade promotes the neutrophil- and macrophage- mediated release of pro-inflammatory cytokines and/or chemokines, as well as their migration and thereby amplifies inflammatory responses that are triggered by bacterial and fungal infections (PubMed:17568691, PubMed:17098818). By also promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptor (TLR) and NOD-like receptor engagement, plays a major role in the pathophysiology of acute and chronic inflammatory diseases of different etiologies including septic shock and atherosclerosis (PubMed:21393102, PubMed:11323674). |
| Cellular Location | [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Note=Recruited to lipid rafts when activated. |
| Tissue Location | Mostly expressed by immune cells of the myeloid lineage, such as monocytes, macrophages, neutrophils and dendritic cells (PubMed:10799849). Expression is associated with a mature stage of myeloid development (PubMed:11922939). Highly expressed in adult liver, lung and spleen than in corresponding fetal tissue. Also expressed in the lymph node, placenta, spinal cord and heart tissues Isoform 2 was detected in the lung, liver and mature monocytes |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Monocyte/macrophage- and neutrophil-mediated inflammatoryresponses can be stimulated through a variety of receptors,including G protein-linked 7-transmembrane receptors (e.g., FPR1;MIM 136537), Fc receptors (see MIM 146790), CD14 (MIM 158120) andToll-like receptors (e.g., TLR4; MIM 603030), and cytokinereceptors (e.g., IFNGR1; MIM 107470). Engagement of these receptorscan also prime myeloid cells to respond to other stimuli. Myeloidcells express receptors belonging to the Ig superfamily, such asTREM1, or to the C-type lectin superfamily. Depending on theirtransmembrane and cytoplasmic sequence structure, these receptorshave either activating (e.g., KIR2DS1; MIM 604952) or inhibitoryfunctions (e.g., KIR2DL1; MIM 604936).
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Tomita, H., et al. J. Rheumatol. 37(4):787-791(2010)Haselmayer, P., et al. J Innate Immun 1(6):582-591(2009)Kim, J., et al. Clin. Exp. Rheumatol. 27(5):773-778(2009)
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