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SCRIB Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q14160 |
|---|---|
| Clone Names | 100623021 |
| Gene ID | 23513 |
|---|---|
| Other Names | Protein scribble homolog, Scribble, hScrib, Protein LAP4, SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SCRIB |
|---|---|
| Synonyms | CRIB1, KIAA0147, LAP4, SCRB1, VARTUL |
| Function | Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:19041750, PubMed:18716323, PubMed:18641685, PubMed:16965391, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Most probably functions in the establishment of apico- basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling (PubMed:18716323, PubMed:18641685). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity. |
| Cellular Location | Cell membrane; Peripheral membrane protein. Cell junction. Cell junction, adherens junction. Cell projection, lamellipodium. Cytoplasm. Postsynapse. Presynapse. Note=Targeting to cell-cell junctions which is CDH1-dependent is required for the pro-apoptotic activity. In a subset of CD4+ T-cells, colocalizes with CRTAM at the immunological synapse during the late phase of T-cell activation (By similarity) {ECO:0000250|UniProtKB:Q80U72} |
| Tissue Location | Expressed in kidney, skeletal muscles, liver, lung, breast, intestine, placenta and skin mainly in epithelial cells (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
SCRIB is a cytoplasmic multimodular scaffold proteintargeted to epithelial adherens junctions and neuronal presynapticcompartments. SCRIB and its orthologs in vertebrates andinvertebrates participate in cell polarization (summary by Nola etal., 2008 [PubMed 18716323]).
References
Liu, H., et al. J. Virol. 84(21):11164-11174(2010)Nagasaka, K., et al. Oncogene 29(38):5311-5321(2010)Ivanov, A.I., et al. Am. J. Pathol. 176(1):134-145(2010)Ouyang, Z., et al. Oncol. Res. 18 (11-12), 593-599 (2010) :Arnaud, C., et al. FEBS Lett. 583(14):2326-2332(2009)
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