|Other Names||Integrin alpha-7, Integrin alpha-7 heavy chain, Integrin alpha-7 light chain, Integrin alpha-7 70 kDa form, ITGA7|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation (By similarity). Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Isoforms containing segment A are predominantly expressed in skeletal muscle. Isoforms containing segment B are abundantly expressed in skeletal muscle, moderately in cardiac muscle, small intestine, colon, ovary and prostate and weakly in lung and testes. Isoforms containing segment X2D are expressed at low levels in fetal and adult skeletal muscle and in cardiac muscle, but are not detected in myoblasts and myotubes. In muscle fibers isoforms containing segment A and B are expressed at myotendinous and neuromuscular junctions; isoforms containing segment C are expressed at neuromuscular junctions and at extrasynaptic sites. Isoforms containing segments X1 or X2 or, at low levels, X1X2 are expressed in fetal and adult skeletal muscle (myoblasts and myotubes) and cardiac muscle|
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The protein encoded by this gene belongs to the integrinalpha chain family. Integrins are heterodimeric integral membraneproteins composed of an alpha chain and a beta chain. They mediatea wide spectrum of cell-cell and cell-matrix interactions, and thusplay a role in cell migration, morphologic development,differentiation, and metastasis. This protein functions as areceptor for the basement membrane protein laminin-1. It is mainlyexpressed in skeletal and cardiac muscles and may be involved indifferentiation and migration processes during myogenesis. Defectsin this gene are associated with congenital myopathy. Alternativelyspliced transcript variants encoding different isoforms have beennoted for this gene.
Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)Han, Y.C., et al. Cancer Res. 70(11):4375-4384(2010)Rooney, J.E., et al. Proc. Natl. Acad. Sci. U.S.A. 106(19):7991-7996(2009)Liu, J., et al. J. Biol. Chem. 283(51):35668-35678(2008)Tran, T., et al. Am. J. Respir. Cell Mol. Biol. 37(6):668-680(2007)
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