|Other Names||Retinoic acid receptor responder protein 3, 311-, HRAS-like suppressor 4, HRSL4, RAR-responsive protein TIG3, Retinoid-inducible gene 1 protein, Tazarotene-induced gene 3 protein, RARRES3, RIG1, TIG3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Exhibits PLA1/2 activity, catalyzing the calcium- independent hydrolysis of acyl groups in various phosphotidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. N- and O-acylation activity is hardly detectable.|
|Cellular Location||Membrane; Single-pass membrane protein|
|Tissue Location||Widely expressed.|
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Retinoids exert biologic effects such as potent growthinhibitory and cell differentiation activities and are used in thetreatment of hyperproliferative dermatological diseases. Theseeffects are mediated by specific nuclear receptor proteins that aremembers of the steroid and thyroid hormone receptor superfamily oftranscriptional regulators. RARRES1, RARRES2, and RARRES3 are geneswhose expression is upregulated by the synthetic retinoidtazarotene. RARRES3 is thought act as a tumor suppressor or growthregulator.
Silva, L.K., et al. Eur. J. Hum. Genet. 18(11):1221-1227(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Uyama, T., et al. Biochim. Biophys. Acta 1791(12):1114-1124(2009)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Higuchi, E., et al. Oncogene 22(30):4627-4635(2003)
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