|Other Names||Neurexin-3-beta, Neurexin III-beta, Neurexin-3-beta, soluble form, Neurexin-3-beta, C-terminal fragment, NRXN3-CTF, NRXN3, KIAA0743|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May play a role in angiogenesis (By similarity).|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed in the blood vessel walls (at protein level).|
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Neurexins are a family of proteins that function in thevertebrate nervous system as cell adhesion molecules and receptors.They are encoded by several unlinked genes of which two, NRXN1 andNRXN3, are among the largest known human genes. Three of the genes(NRXN1-3) utilize two alternate promoters and include numerousalternatively spliced exons to generate thousands of distinct mRNAtranscripts and protein isoforms. The majority of transcripts areproduced from the upstream promoter and encode alpha-neurexinisoforms; a much smaller number of transcripts are produced fromthe downstream promoter and encode beta-neurexin isoforms. Thealpha-neurexins contain epidermal growth factor-like (EGF-like)sequences and laminin G domains, and have been shown to interactwith neurexophilins. The beta-neurexins lack EGF-like sequences andcontain fewer laminin G domains than alpha-neurexins. [provided byRefSeq].
Saus, E., et al. J Psychiatr Res 44(14):971-978(2010)Hotta, K., et al. J. Hum. Genet. (2010) In press :Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Cirulli, E.T., et al. Eur. J. Hum. Genet. 18(7):815-820(2010)Novak, G., et al. World J. Biol. Psychiatry 10 (4 PT 3), 929-935 (2009) :
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