|Other Names||P2X purinoceptor 3, P2X3, ATP receptor, Purinergic receptor, P2RX3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for ATP that acts as a ligand-gated ion channel.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
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The product of this gene belongs to the family ofpurinoceptors for ATP. This receptor functions as a ligand-gatedion channel and may transduce ATP-evoked nociceptor activation.Mouse studies suggest that this receptor is important forperipheral pain responses, and also participates in pathwayscontrolling urinary bladder volume reflexes. It is possible thatthe development of selective antagonists for this receptor may havea therapeutic potential in pain relief and in the treatment ofdisorders of urine storage.
Allsopp, R.C., et al. J. Biol. Chem. 285(43):32770-32777(2010)Beneng, K., et al. Int J Oral Maxillofac Surg 39(8):815-819(2010)Nair, A., et al. Cell. Mol. Neurobiol. 30(4):505-509(2010)Jacques-Silva, M.C., et al. Proc. Natl. Acad. Sci. U.S.A. 107(14):6465-6470(2010)Varani, K., et al. Cell. Physiol. Biochem. 25 (2-3), 325-336 (2010) :
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