|Other Names||Polycomb group RING finger protein 6, Mel18 and Bmi1-like RING finger, RING finger protein 134, PCGF6, MBLR, RNF134|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene contains a RING fingermotif, which is most closely related to those of polycomb group(PcG) proteins RNF110/MEL-18 and BMI1. PcG proteins are known toform protein complexes and function as transcription repressors.This protein has been shown to interact with some PcG proteins andact as a transcription repressor. The activity of this protein isfound to be regulated by cell cycle dependent phosphorylation.Alternatively spliced transcript variants encoding differentisoforms have been identified.
Lee, J.Y., et al. Cancer Res. 68(11):4201-4209(2008)Zhang, J., et al. J. Biol. Chem. 283(12):7464-7469(2008)Lee, M.G., et al. Cell 128(5):877-887(2007)Zhong, N., et al. Biochem. Biophys. Res. Commun. 338(2):855-861(2005)Deloukas, P., et al. Nature 429(6990):375-381(2004)
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