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PCGF6 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9BYE7
Clone Names 110901037
Peptide ID 110901037
Additional Information
Gene ID 84108
Other Names Polycomb group RING finger protein 6, Mel18 and Bmi1-like RING finger, RING finger protein 134, PCGF6, MBLR, RNF134
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PCGF6
Synonyms MBLR, RNF134
Function Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
Cellular Location Nucleus
Tissue Location Ubiquitous.
Research Areas
Citations (0)

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Background

The protein encoded by this gene contains a RING fingermotif, which is most closely related to those of polycomb group(PcG) proteins RNF110/MEL-18 and BMI1. PcG proteins are known toform protein complexes and function as transcription repressors.This protein has been shown to interact with some PcG proteins andact as a transcription repressor. The activity of this protein isfound to be regulated by cell cycle dependent phosphorylation.Alternatively spliced transcript variants encoding differentisoforms have been identified.

References

Lee, J.Y., et al. Cancer Res. 68(11):4201-4209(2008)Zhang, J., et al. J. Biol. Chem. 283(12):7464-7469(2008)Lee, M.G., et al. Cell 128(5):877-887(2007)Zhong, N., et al. Biochem. Biophys. Res. Commun. 338(2):855-861(2005)Deloukas, P., et al. Nature 429(6990):375-381(2004)

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$ 80.00
Cat# BP18850c
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