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PDLIM3 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q53GG5
Clone Names 110901041
Peptide ID 110901041
Additional Information
Gene ID 27295
Other Names PDZ and LIM domain protein 3, Actinin-associated LIM protein, Alpha-actinin-2-associated LIM protein, PDLIM3, ALP
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PDLIM3
Synonyms ALP
Function May play a role in the organization of actin filament arrays within muscle cells.
Cellular Location Cytoplasm, myofibril, sarcomere, Z line. Note=Localizes to myofiber Z-lines
Tissue Location Isoform 1 is highly expressed in differentiated skeletal muscle. Isoform 2 is heart-specific
Research Areas
Citations (0)

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Background

The protein encoded by this gene contains a PDZ domain anda LIM domain, indicating that it may be involved in cytoskeletalassembly. In support of this, the encoded protein has been shown tobind the spectrin-like repeats of alpha-actinin-2 and to colocalizewith alpha-actinin-2 at the Z lines of skeletal muscle. This geneis found near a region of chromosome 4 that has been implicated infacioscapulohumeral muscular dystrophy, but this gene does notappear to be involved in the disease. Two transcript variantsencoding different isoforms have been found for this gene.

References

Hershberger, R.E., et al. Clin Transl Sci 1(1):21-26(2008)Keira, Y., et al. Neurosci. Res. 57(4):513-521(2007)Arola, A.M., et al. Mol. Genet. Metab. 90(4):435-440(2007)Klaavuniemi, T., et al. J. Biol. Chem. 279(25):26402-26410(2004)Bouju, S., et al. Neuromuscul. Disord. 9(1):3-10(1999)

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$ 80.00
Cat# BP18851b
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