|Other Names||PDZ and LIM domain protein 3, Actinin-associated LIM protein, Alpha-actinin-2-associated LIM protein, PDLIM3, ALP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in the organization of actin filament arrays within muscle cells.|
|Cellular Location||Cytoplasm, myofibril, sarcomere, Z line. Note=Localizes to myofiber Z-lines|
|Tissue Location||Isoform 1 is highly expressed in differentiated skeletal muscle. Isoform 2 is heart-specific|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene contains a PDZ domain anda LIM domain, indicating that it may be involved in cytoskeletalassembly. In support of this, the encoded protein has been shown tobind the spectrin-like repeats of alpha-actinin-2 and to colocalizewith alpha-actinin-2 at the Z lines of skeletal muscle. This geneis found near a region of chromosome 4 that has been implicated infacioscapulohumeral muscular dystrophy, but this gene does notappear to be involved in the disease. Two transcript variantsencoding different isoforms have been found for this gene.
Hershberger, R.E., et al. Clin Transl Sci 1(1):21-26(2008)Keira, Y., et al. Neurosci. Res. 57(4):513-521(2007)Arola, A.M., et al. Mol. Genet. Metab. 90(4):435-440(2007)Klaavuniemi, T., et al. J. Biol. Chem. 279(25):26402-26410(2004)Bouju, S., et al. Neuromuscul. Disord. 9(1):3-10(1999)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.