|Other Names||E3 ubiquitin-protein ligase pellino homolog 1, Pellino-1, 632-, Pellino-related intracellular-signaling molecule, PELI1, PRISM|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation.|
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Provided below are standard protocols that you may find useful for product applications.
Scaffold protein involved in the IL-1 signaling pathway via its interaction with the complex containing IRAK kinases and TRAF6. Required for NF-kappa-B activation and IL-8 gene expression in response to IL-1.
Ordureau, A., et al. Biochem. J. 409(1):43-52(2008)Butler, M.P., et al. J. Biol. Chem. 282(41):29729-29737(2007)Lamesch, P., et al. Genomics 89(3):307-315(2007)Choi, K.C., et al. Nat. Immunol. 7(10):1057-1065(2006)Butler, M.P., et al. J. Biol. Chem. 280(30):27759-27768(2005)
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