|Other Names||Perilipin-3, 47 kDa mannose 6-phosphate receptor-binding protein, 47 kDa MPR-binding protein, Cargo selection protein TIP47, Mannose-6-phosphate receptor-binding protein 1, Placental protein 17, PP17, PLIN3, M6PRBP1, TIP47|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network.|
|Cellular Location||Cytoplasm. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lipid droplet. Note=Membrane associated on endosomes. Detected in the envelope and the core of lipid bodies and in lipid sails|
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Provided below are standard protocols that you may find useful for product applications.
Mannose 6-phophate receptors (MPRs) deliver lysosomalhydrolase from the Golgi to endosomes and then return to the Golgicomplex. The protein encoded by this gene interacts with thecytoplasmic domains of both cation-independent and cation-dependentMPRs, and is required for endosome-to-Golgi transport. This proteinalso binds directly to the GTPase RAB9 (RAB9A), a member of the RASoncogene family. The interaction with RAB9 has been shown toincrease the affinity of this protein for its cargo. Multipletranscript variants encoding different isoforms have been found forthis gene.
Hocsak, E., et al. FEBS Lett. 584(13):2953-2960(2010)Bauby, H., et al. Traffic 11(4):455-467(2010)Kimmel, A.R., et al. J. Lipid Res. 51(3):468-471(2010)Espinosa, E.J., et al. Cell 137(5):938-948(2009)Bulankina, A.V., et al. J. Cell Biol. 185(4):641-655(2009)
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