|Other Names||Prickle-like protein 1, REST/NRSF-interacting LIM domain protein 1, PRICKLE1, RILP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure. Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor.|
|Cellular Location||Nucleus membrane. Cytoplasm, cytosol. Note=A smaller amount is detected in the cytosol|
|Tissue Location||Expressed at highest levels in placenta and at lower levels in lung, liver, kidney and pancreas. Expressed in thalamus, hippocampus, cerebral cortex, and cerebellum (in neurons rather than glia).|
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This gene encodes a nuclear receptor that may be anegative regulator of the Wnt/beta-catenin signaling pathway. Theencoded protein localizes to the nuclear membrane and has beenimplicated in the nuclear trafficking of the transcriptionrepressors REST/NRSF and REST4. Mutations in this gene have beenlinked to progressive myoclonus epilepsy. Alternate splicingresults in multiple transcript variants. A pseudogene of this geneis found on chromosome 3.
Smith, N.L., et al. Circ Cardiovasc Genet 3(3):256-266(2010)Wheeler, H.E., et al. PLoS Genet. 5 (10), E1000685 (2009) :Perry, J.R., et al. Diabetes 58(6):1463-1467(2009)Narimatsu, M., et al. Cell 137(2):295-307(2009)Shimojo, M. J. Biol. Chem. 283(50):34880-34886(2008)
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