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VSIG4 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9Y279
Clone Names 110901252
Additional Information
Gene ID 11326
Other Names V-set and immunoglobulin domain-containing protein 4, Protein Z39Ig, VSIG4, CRIg, Z39IG
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name VSIG4
Synonyms CRIg, Z39IG
Function Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pathway convertases.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Abundantly expressed in several fetal tissues. In adult tissues, highest expression in lung and placenta. Expressed in resting macrophages.
Research Areas
Citations (0)
citation

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Background

This gene encodes a v-set and immunoglobulin-domaincontaining protein that is structurally related to the B7 family ofimmune regulatory proteins. The encoded protein may be a negativeregulator of T-cell responses. This protein is also a receptor forthe complement component 3 fragments C3b and iC3b. Alternatesplicing results in multiple transcript variants. [provided byRefSeq].

References

Guo, S., et al. Clin. Immunol. 136(2):282-291(2010)Van Loo, P., et al. Haematologica 95(3):440-448(2010)Xu, S., et al. Immunol. Lett. 128(1):46-50(2010)He, J.Q., et al. Mol. Immunol. 45(16):4041-4047(2008)Vogt, L., et al. J. Clin. Invest. 116(10):2817-2826(2006)

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$ 277.78
Cat# BP18884b
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