|Other Names||V-set and immunoglobulin domain-containing protein 4, Protein Z39Ig, VSIG4, CRIg, Z39IG|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pathway convertases.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Abundantly expressed in several fetal tissues. In adult tissues, highest expression in lung and placenta Expressed in resting macrophages.|
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This gene encodes a v-set and immunoglobulin-domaincontaining protein that is structurally related to the B7 family ofimmune regulatory proteins. The encoded protein may be a negativeregulator of T-cell responses. This protein is also a receptor forthe complement component 3 fragments C3b and iC3b. Alternatesplicing results in multiple transcript variants. [provided byRefSeq].
Guo, S., et al. Clin. Immunol. 136(2):282-291(2010)Van Loo, P., et al. Haematologica 95(3):440-448(2010)Xu, S., et al. Immunol. Lett. 128(1):46-50(2010)He, J.Q., et al. Mol. Immunol. 45(16):4041-4047(2008)Vogt, L., et al. J. Clin. Invest. 116(10):2817-2826(2006)
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