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IKKB Antibody (C-term S689) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O14920
Clone Names 111026254
Peptide ID 111026254
Additional Information
Gene ID 3551
Other Names Inhibitor of nuclear factor kappa-B kinase subunit beta, I-kappa-B-kinase beta, IKK-B, IKK-beta, IkBKB, I-kappa-B kinase 2, IKK2, Nuclear factor NF-kappa-B inhibitor kinase beta, NFKBIKB, IKBKB, IKKB
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms IKKB
Function Serine kinase that plays an essential role in the NF- kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.
Cellular Location Cytoplasm. Nucleus. Membrane raft. Note=Colocalized with DPP4 in membrane rafts
Tissue Location Highly expressed in heart, placenta, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis and peripheral blood
Research Areas
Citations (0)

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NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL(MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form theNFKB complex. The NFKB complex is inhibited by I-kappa-B proteins(NFKBIA, MIM 164008, or NFKBIB, MIM 604495), which inactivateNF-kappa-B by trapping it in the cytoplasm. Phosphorylation ofserine residues on the I-kappa-B proteins by kinases (IKBKA, MIM600664, or IKBKB) marks them for destruction via the ubiquitinationpathway, thereby allowing activation of the NF-kappa-B complex.Activated NFKB complex translocates into the nucleus and binds DNAat kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or Gpurine; and Y is a C or T pyrimidine).


Yatherajam, G., et al. J. Immunol. 185(5):2665-2669(2010)Kenneth, N.S., et al. EMBO J. 29(17):2966-2978(2010)Zhao, M., et al. J. Biol. Chem. 285(32):24372-24380(2010)Niida, M., et al. Mol. Immunol. 47(14):2378-2387(2010)Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010)

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$ 80.00
Cat# BP18899b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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